Secondary metabolites produced by actinomycete strains undoubtedly have great potential
for use in applied research areas such as drug discovery. However, it is becoming difficult to …

Actinomycetes genome sequencing and bioinformatic analyses revealed a large number of
“cryptic” gene clusters coding for secondary metabolism. These gene clusters have the …

Actinomycetes are prolific sources of bioactive molecules. Traditional workflows including
bacterial isolation, fermentation, metabolite identification and structure elucidation have …

Genomic sequence data have revealed the presence of a large fraction of putatively silent
biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary …

Actinobacterial natural products showed a critical basis for the discovery of new antibiotics
as well as other lead secondary metabolites. Varied environmental and physiological …

Actinomycetes represent the microbial group richest in production of variable secondary
metabolites. These mostly bioactive molecules are the end products of complex multistep …

Actinomycetes are still one of the most important sources of chemical diversity and a
reservoir to mine for novel structures that are requiring the integration of diverse disciplines …

Microorganisms are more beneficial than being dangerous for humans. Microbial secondary
metabolites and other bioactive compounds are revealed to be highly used in …

Production of secondary metabolites is a process influenced by several physico-chemical
factors including nutrient supply, oxygenation, temperature and pH. These factors have been …

The discovery and development of actinomycete secondary metabolites (ASMs) have
played pivotal roles in the fields of human medicine and its related biotechnology sectors …