Digital and precision clinical trials: Innovations for testing mental health medications, devices, and psychosocial treatments

E Lenze, J Torous, P Arean - Neuropsychopharmacology, 2024 - nature.com
Mental health treatment advances-including neuropsychiatric medications and devices,
psychotherapies, and cognitive treatments-lag behind other fields of clinical medicine such …

The case for practical clinical trials in psychiatry

JS March, SG Silva, S Compton… - American Journal of …, 2005 - Am Psychiatric Assoc
OBJECTIVE: Clinical trials in psychiatry frequently fail to maximize clinical utility for
practicing clinicians, or, stated differently, available evidence is not perceived by clinicians …

[HTML][HTML] Evidence‐informed is not enough: digital therapeutics also need to be evidence‐based

CA Espie, J Firth, J Torous - World Psychiatry, 2022 - ncbi.nlm.nih.gov
World Psychiatry 21: 2-June 2022 321 products that are specifically designed for user
engagement3. These standards are all the more necessary as user engagement is often far …

A framework for advancing precision medicine in clinical trials for mental disorders

EJ Lenze, TL Rodebaugh, GE Nicol - JAMA psychiatry, 2020 - jamanetwork.com
Getting the right treatment to the right patient is a frustrating goal in mental health: treatment
is a trial-anderror endeavor, often yielding disappointing outcomes. Why? Traditional …

Enhancing the technology of clinical trials and the trials model to evaluate newly developed, targeted antidepressants

MM Katz, UM Halbreich, CL Bowden, A Frazer… - …, 2002 - Elsevier
Concern about disappointing results from recent multi-center trials of new antidepressants
prompted several ACNP workshops on “improving the technology of clinical trials.” The …

Scaling evidence-based treatments through digital mental health.

SM Schueller, J Torous - American Psychologist, 2020 - psycnet.apa.org
A large number of Internet websites, mobile apps, wearable devices, and video games that
are hoped to improve behavioral, cognitive, and affective targets associated with mental …

[图书][B] Modern clinical trial analysis

W Tang, X Tu - 2012 - Springer
With advances in medical sciences, cancer research no longer focuses primarily on effective
treatments, but rather a host of other issues such as tools for early diagnosis, cost of …

[HTML][HTML] Evaluation of randomized controlled trials: a primer and tutorial for mental health researchers

M Harrer, P Cuijpers, LKJ Schuurmans, T Kaiser… - Trials, 2023 - Springer
Background Considered one of the highest levels of evidence, results of randomized
controlled trials (RCTs) remain an essential building block in mental health research. They …

Neuropsychiatric clinical trials: should they accommodate real-world practices or set standards for clinical practices?

RE Becker, NH Greig - Journal of clinical psychopharmacology, 2009 - journals.lww.com
Evidence-based psychiatry seeks the best research evidence for use in patient care. Recent
research suggests that problems with accuracy, precision, bias, and other sources of …

Tracing Digital Therapeutics Research Across Medical Specialties: Evidence from ClinicalTrials. gov

L Masanneck, AD Stern - Clinical Pharmacology & …, 2024 - Wiley Online Library
Digital therapeutics (DTx), evidence‐based software interventions for preventing, managing,
or treating medical disorders, have rapidly evolved with healthcare's shift toward online …