Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in …

DH Abu-Baih, AAR Gomaa, NM Abdel-Wahab… - … Medicine and Therapies, 2024 - Springer
Background Gastric ulcers represent a worldwide health problem, characterized by erosions
that affect the mucous membrane of the stomach and may even reach the muscular layer …

[HTML][HTML] Apple extract protects against indomethacin-induced gastric ulcers in rats by suppressing oxidative stress–The implication of Nrf-2/HO-1 signaling pathway: In …

ER Abdelaleem, MF Abdelwahab… - Journal of Functional …, 2024 - Elsevier
Gastric ulcers represent a worldwide health problem, characterized by erosions with
different degrees in the gastrointestinal mucosa. In the current study, we explore the …

Unveiling the potential mechanisms of Amomi fructus against gastric ulcers via integrating network pharmacology and in vivo experiments

Y Lv, J Li, Y Li, J Su, X Ding, Y Yuan, S Liu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance As a well-known traditional Chinese medicine, Amomi
fructus (A. fructus)(Sharen) has been used therapeutically to treat gastrointestinal illnesses …

[HTML][HTML] Protective potential of ethylacetate extract of Abrus precatorius (Linn) seeds against HCl/EtOH-induced gastric ulcer via pro-inflammatory regulation: In vivo …

DA Omoboyowa, OM Omomule, TA Balogun… - Phytomedicine Plus, 2021 - Elsevier
Background Gastric ulcer is the most common gastrointestinal disorder of the stomach which
has become global health challenge. Management with natural therapeutic agents such as …

Antiulcer Potential of Psidium guajava Seed Extract Supported by Metabolic Profiling and Molecular Docking

NH Shady, HS Abdullah, SA Maher, A Albohy… - Antioxidants, 2022 - mdpi.com
One of the most severe human health problems is gastric ulceration. The main aim of our
study is to explore the gastroprotective effect of the Psidium guajava seeds extract (PGE) …

Integrated metabolomics and network pharmacology to decipher the latent mechanisms of protopanaxatriol against acetic acid-induced gastric ulcer

C Wang, L Tan, J Liu, D Fu, C Wang, P Li, Z Li… - International Journal of …, 2022 - mdpi.com
Gastric ulcer (GU) is a peptic disease with high morbidity and mortality rates affecting
approximately 4% of the population throughout the world. Current therapies for GU are …

Gastroprotective potential of red onion (Allium cepa L.) peel in ethanol-induced gastric injury in rats: involvement of Nrf2/HO-1 and HMGB-1/NF-κB trajectories

NB Ali, SSA Ibrahim, MA Alsherbiny, E Sheta… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance The utilization of plants with therapeutic properties in
traditional medicine has a longstanding practice. Among them, the well-known Allium cepa …

Network Pharmacology and Molecular Docking Analysis on Pharmacological Mechanisms of Astragalus membranaceus in the Treatment of Gastric Ulcer

P Zhou, R Zhou, Y Min, LP An… - Evidence‐Based …, 2022 - Wiley Online Library
Background. Astragalus membranaceus (AM, family: Leguminosae) exerts significant
therapeutic effect on gastric ulcer (GU); however, there are scarce studies on its molecular …

Ipomoea carnea mitigates ethanol-induced ulcers in irradiated rats via Nrf2/HO−1 pathway: an in vivo and in silico study

MA Ghareeb, HS Mohammed, T Aboushousha… - Scientific Reports, 2024 - nature.com
The aim of this study was to investigate the potential of Ipomoea carnea flower methanolic
extract (ICME) as a natural gastroprotective therapy against ethanol-induced gastric ulcers …

LC–ESI–MS phenolic contents assessment, antioxidant, and protective ability of Punica granatum root bark extract against ethanol-induced gastric ulcer in rats: in …

H Alimi, FH Mabrouk, N Zouari, M Sakly… - Toxicology …, 2023 - academic.oup.com
The objectives of the current study were to evaluate the Punica granatum root bark extract's
(PGE) antioxidant and gastroprotective activities against ethanol-induced gastric ulcers in …