Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency-a systematic review …

AM Faizal, MH Elias, NM Jin, MA Abu… - Frontiers in …, 2024 - frontiersin.org
The leading indicator for successful outcomes in in-vitro fertilization (IVF) is the quality of
gametes in oocytes and sperm. Thus, advanced research aims to highlight the parameter in …

PCOS and role of cumulus gene expression in assessing oocytes quality

N Sayutti, MA Abu, MF Ahmad - Frontiers in Endocrinology, 2022 - frontiersin.org
The global infertility rate has been declining from year to year. PCOS is one of the treatable
accountable causes contributing to anovulatory infertility. Nevertheless, the success rate of …

Bioinformatic analysis of human cumulus cells to unravel cellular's processes that could be used to establish oocyte quality biomarkers with clinical application

L von Mengden, MA De Bastiani, LK Grun… - Reproductive …, 2023 - Springer
Metadata analysis of public microarray datasets using bioinformatics tools has been
successfully used in several biomedical fields in the search for biomarkers. In reproductive …

[HTML][HTML] Human cumulus cell gene expression as a biomarker of pregnancy outcome after single embryo transfer

KM Gebhardt, DK Feil, KR Dunning, M Lane… - Fertility and sterility, 2011 - Elsevier
Objective To identify the cumulus cell gene expression associated with oocyte
developmental competence, specifically live birth, after single ET (SET) assisted …

Stratifying cumulus cell samples based on molecular profiling to help resolve biomarker discrepancies and to predict oocyte developmental competence

O El-Maarri, MA Jamil, M Köster, N Nüsgen… - International Journal of …, 2021 - mdpi.com
To increase the efficiency of assisted reproductive techniques (ART), molecular studies have
been performed to identify the best predictive biomarkers for selecting the most suitable …

Comparative gene expression profiling in human cumulus cells according to ovarian gonadotropin treatments

S Assou, D Haouzi, H Dechaud, A Gala… - BioMed Research …, 2013 - Wiley Online Library
In in vitro fertilization cycles, both HP‐hMG and rFSH gonadotropin treatments are widely
used to control human follicle development. The objectives of this study are (i) to …

GPX3 Overexpression in Cumulus Cells Entails a Poor Prognosis for Uterine Implantation of Morphotype A Embryos

I Bejarano, M Dorado-Silva, H Sarmiento-Soto… - Biology, 2022 - mdpi.com
Simple Summary Despite the fact that human assisted reproduction has undergone
extensive development with positive effects on pregnancy, the rates of success are still low …

RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte/embryo competence and potentially reliable predictors of embryo …

X Huang, C Hao, X Shen, Y Zhang, X Liu - Reproductive Biology and …, 2013 - Springer
Background Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic
disorder in women. The developmental competence of oocytes and embryos in PCOS …

Transcriptomic analysis and meta-analysis of human granulosa and cumulus cells

T Burnik Papler, E Vrtacnik Bokal, A Maver, AN Kopitar… - PloS one, 2015 - journals.plos.org
Specific gene expression in oocytes and its surrounding cumulus (CC) and granulosa (GC)
cells is needed for successful folliculogenesis and oocyte maturation. The aim of the present …

The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome

Z Huang, D Wells - Molecular human reproduction, 2010 - academic.oup.com
It is widely recognized that bi-directional communication exists between the human oocyte
and cumulus cells (CCs) which is essential for the production of competent oocytes. CCs …