Relapse to drug use during abstinence is a defining feature of addiction. To date, however,
results from studies using rat relapse/reinstatement models have yet to result in FDA …

A main challenge in addiction treatment is high relapse rates during abstinence. This clinical
scenario has been traditionally studied using animal models of relapse in which drug …

Successful treatment of drug addiction must involve relapse prevention informed by our
understanding of the neurobiological bases of drug relapse. In humans, exposure to drug …

Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …

Understanding and preventing relapse to drug use is one of the most difficult challenges
faced by clinicians and practitioners in the struggle to help people remain abstinent. In this …

Background Treatment strategies that aim to promote abstinence to heroin use and reduce
vulnerability to drug-use resumption are limited in sustainability and long-term efficacy. We …

Maintaining abstinence and preventing relapse are key to the successful recovery from
alcohol use disorder. There are two main ways individuals with alcohol use disorder abstain …

In the classical incubation of drug craving rat model, drug seeking is assessed after
homecage forced abstinence. However, human abstinence is often voluntary because …

High relapse rate is a key feature of opioid addiction. In humans, abstinence is often
voluntary due to negative consequences of opioid seeking. To mimic this human condition …

Rationale and objectives Heroin addiction is a significant health and societal problem for
which there is no highly effective long-term behavioral or pharmacological treatment …