[HTML][HTML] Cell-type brain-region specific changes in prefrontal cortex of a mouse model of alcohol dependence
NA Salem, L Manzano, MW Keist, O Ponomareva… - Neurobiology of …, 2024 - Elsevier
The prefrontal cortex is a crucial regulator of alcohol drinking, and dependence, and other
behavioral phenotypes associated with AUD. Comprehensive identification of cell-type …
behavioral phenotypes associated with AUD. Comprehensive identification of cell-type …
Brain regional gene expression network analysis identifies unique interactions between chronic ethanol exposure and consumption
Progressive increases in ethanol consumption is a hallmark of alcohol use disorder (AUD).
Persistent changes in brain gene expression are hypothesized to underlie the altered neural …
Persistent changes in brain gene expression are hypothesized to underlie the altered neural …
Glial gene networks associated with alcohol dependence
Chronic alcohol abuse alters the molecular structure and function of brain cells. Recent work
suggests adaptations made by glial cells, such as astrocytes and microglia, regulate …
suggests adaptations made by glial cells, such as astrocytes and microglia, regulate …
Cross-species co-analysis of prefrontal cortex chronic ethanol transcriptome responses in mice and monkeys
JW Bogenpohl, ML Smith, SP Farris… - Frontiers in molecular …, 2019 - frontiersin.org
Despite recent extensive genomic and genetic studies on behavioral responses to ethanol,
relatively few new therapeutic targets for the treatment of alcohol use disorder have been …
relatively few new therapeutic targets for the treatment of alcohol use disorder have been …
Transcriptional profiling of the rat nucleus accumbens after modest or high alcohol exposure
Alcohol use disorder is a chronic relapsing brain disorder and a global health issue.
Prolonged high alcohol consumption increases the risk for dependence development, a …
Prolonged high alcohol consumption increases the risk for dependence development, a …
Alcohol dependence in rats is associated with global changes in gene expression in the central amygdala
BR Kisby, SP Farris, MM McManus, FP Varodayan… - Brain sciences, 2021 - mdpi.com
Alcohol dependence is associated with adverse consequences of alcohol (ethanol) use and
is evident in most severe cases of alcohol use disorder (AUD). The central nucleus of the …
is evident in most severe cases of alcohol use disorder (AUD). The central nucleus of the …
Dissecting brain networks underlying alcohol binge drinking using a systems genomics approach
LB Ferguson, L Zhang, D Kircher, S Wang… - Molecular …, 2019 - Springer
Alcohol use disorder (AUD) is a complex psychiatric disorder with strong genetic and
environmental risk factors. We studied the molecular perturbations underlying risky drinking …
environmental risk factors. We studied the molecular perturbations underlying risky drinking …
Time-course analysis of brain regional expression network responses to chronic intermittent ethanol and withdrawal: implications for mechanisms underlying …
Long lasting abusive consumption, dependence, and withdrawal are characteristic features
of alcohol use disorders (AUD). Mechanistically, persistent changes in gene expression are …
of alcohol use disorders (AUD). Mechanistically, persistent changes in gene expression are …
Cross-species alcohol dependence-associated gene networks: Co-analysis of mouse brain gene expression and human genome-wide association data
Genome-wide association studies on alcohol dependence, by themselves, have yet to
account for the estimated heritability of the disorder and provide incomplete mechanistic …
account for the estimated heritability of the disorder and provide incomplete mechanistic …
Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking
O George, C Sanders, J Freiling… - Proceedings of the …, 2012 - National Acad Sciences
Chronic intermittent access to alcohol leads to the escalation of alcohol intake, similar to
binge drinking in humans. Converging lines of evidence suggest that impairment of medial …
binge drinking in humans. Converging lines of evidence suggest that impairment of medial …
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