The prefrontal cortex is a crucial regulator of alcohol drinking, and dependence, and other
behavioral phenotypes associated with AUD. Comprehensive identification of cell-type …

Progressive increases in ethanol consumption is a hallmark of alcohol use disorder (AUD).
Persistent changes in brain gene expression are hypothesized to underlie the altered neural …

Chronic alcohol abuse alters the molecular structure and function of brain cells. Recent work
suggests adaptations made by glial cells, such as astrocytes and microglia, regulate …

Despite recent extensive genomic and genetic studies on behavioral responses to ethanol,
relatively few new therapeutic targets for the treatment of alcohol use disorder have been …

Alcohol use disorder is a chronic relapsing brain disorder and a global health issue.
Prolonged high alcohol consumption increases the risk for dependence development, a …

Alcohol dependence is associated with adverse consequences of alcohol (ethanol) use and
is evident in most severe cases of alcohol use disorder (AUD). The central nucleus of the …

Alcohol use disorder (AUD) is a complex psychiatric disorder with strong genetic and
environmental risk factors. We studied the molecular perturbations underlying risky drinking …

Long lasting abusive consumption, dependence, and withdrawal are characteristic features
of alcohol use disorders (AUD). Mechanistically, persistent changes in gene expression are …

Genome-wide association studies on alcohol dependence, by themselves, have yet to
account for the estimated heritability of the disorder and provide incomplete mechanistic …

Chronic intermittent access to alcohol leads to the escalation of alcohol intake, similar to
binge drinking in humans. Converging lines of evidence suggest that impairment of medial …