HIV cure still remains an elusive target. The “Shock and Kill” strategy which aims to
reactivate HIV from latently infected cells and subsequently kill them through virally induced …

HIV cure is thwarted by the presence of quiescent yet replication competent HIV-1 (HIV).
Antiretroviral therapy (ART) is unable to eradicate reservoirs, and upon cessation of ART …

HIV infection leads to the progressive loss of CD4+ T cells and the near complete
destruction of the immune system in the majority of infected individuals. High levels of viral …

These recent findings highlight both the antagonistic and agonistic effects of the NF-κB
signaling pathway on HIV-1 latency. Synergistic inducers might be useful for flushing of …

Despite its clinical importance, the molecular biology of HIV-1 latency control is at best
partially understood, and the literature remains conflicting. The most recent description that …

Current combination antiretroviral therapies (cART) are unable to eradicate HIV-1 from
infected individuals because of the establishment of proviral latency in long-lived cellular …

Nuclear factor-κB (NF-κB) is an important transcription factor that induces the expression of
antiviral genes and viral genes. NF-κB activation needs the activation of NF-κB upstream …

NF-kappaB (NF-κB), the transcription factors of HIV-1, play an important role in triggering
HIV transcription. The inhibition of NF-κB activation and their signaling pathway offers a …

Highly active antiretroviral therapy (HAART) is very effective in suppressing HIV-1 replication
and restoring immune functions in HIV-infected individuals. However, it fails to eradicate the …

Latency reversal and subsequent elimination of the human immunodeficiency virus-1 (HIV-
1) reservoir using a combination of compounds with different mechanisms of action are …