Background & Aims Dysregulated colonic epithelial cell (CEC) proliferation is a critical
feature in the development of colorectal cancer. We show that NF-κB-inducing kinase (NIK) …

The NFκB pathway, known as the central regulator of inflammation, has a well-established
role in colorectal cancer (CRC) initiation, progression, and therapy resistance. Due to the …

Dysregulation of NF-κB signaling is a common feature in Colorectal Cancer (CRC). While
the canonical signaling pathway is well characterized, the non-canonical NF-κB signaling …

There is growing evidence for a connection between inflammation and tumor development,
and the nuclear factor kappa B (NF-κB), a proinflammatory transcription factor, is …

Intestinal immunity and homeostasis are maintained through the regulation of cytokine
trafficking, microbiota, necrosis and apoptosis. Intestinal immunity and homeostasis …

Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression
of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes …

Multiple studies have shown that chronic inflammation is closely related to the occurrence
and development of colorectal cancer (CRC). Classical NF-κB signaling, the key factor in …

Purpose: Nuclear factor κB (NF-κB) is an important transcription factor in various biological
processes. Constitutive NF-κB activation has been noted in many tumors, including …

Background Despite the identification of many signaling pathways involved in colorectal
cancer (CRC) tumorigenesis, metastatic CRC still remains one of the major causes of cancer …

The role of NF-κB activation in tumor initiation has not been thoroughly investigated. We
generated Ikkβ (EE) IEC transgenic mice expressing constitutively active IκB kinase β (IKKβ) …