Aneuploidy, a deviation of the chromosome number from euploidy, is one of the hallmarks of
cancer. High levels of aneuploidy are generally correlated with metastasis and poor …

Aneuploidy, or an uneven number of chromosomes, has mostly detrimental consequences
in eukaryotic cells, which include impaired proliferation as well as compromised DNA …

Aneuploidy leads to severe developmental defects in mammals and is also a hallmark of
cancer. However, whether aneuploidy is a driving cause or a consequence of tumor …

Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here,
we investigated the relationship between aneuploidy and cancer development using cells …

Teratoma formation is a critical obstacle to safe clinical translation of human embryonic stem
(ES) cell-based therapies in the future. As current methods of isolation are unable to yield …

Fitness penalties of aneuploidy | Nature Reviews Cancer Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Transformation of human embryonic stem cells (hESC) is of interest to scientists who use
them as a raw material for cell-processed therapeutic products. However, the WHO and ICH …

Teratoma, due to its remarkable ability to differentiate into multiple cell lineages, is a
valuable model for studying human embryonic development. The similarity of the gene …

Genetic and genomic aberrations are the primary cause of cancer. Chromosome
missegregation leads to aneuploidy and provides cancer cells with a mechanism to lose …

The aim of this study was to assess the biological reactions triggered by stem cell
transplantation related to phenotypic alteration, host-to-cell response, chromosomal stability …