The tumor microenvironment (TME) is a complex ecosystem of diverse cell types whose
interactions govern tumor growth and clinical outcome. While the TME's impact on …

Introduction: The tumor microenvironment (TME) is a complex and dynamic ecosystem that
plays critical roles in tumor development and clinical outcome. While the multifarious cellular …

Recent advancements in single-cell RNA sequencing (scRNA-seq) have enabled the
identification of phenotypic diversity within breast tumor tissues. However, the contribution of …

Neoadjuvant chemotherapy (NAC) alone or combined with target therapies represents the
standard of care for localized triple-negative breast cancer (TNBC). However, only a fraction …

To elucidate the effects of neoadjuvant chemotherapy (NAC), we conduct whole
transcriptome profiling coupled with histopathology analyses of a longitudinal breast cancer …

Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast cancers and is
characterized by a high rate of recurrence, despite the improvement of the therapeutic …

Recently, Axelrod and colleagues analyzed immune-related gene expression changes in
breast cancer before and after neoadjuvant chemotherapy (Axelrod et al., 2020). The …

Background Immune system plays an important role in the development, treatment
response, and progression of triple-negative breast cancer. Here, we aimed to assess the …

Simple Summary Triple-negative breast cancer (TNBC) is currently in the clinical research
spotlight because of the tumor's aggressive and invasive nature and the scarcity of …

With a high risk of relapse and death, and a poor or absent response to therapeutics, the
triple-negative breast cancer (TNBC) subtype is particularly challenging, especially in …