Presynaptic Ca2+ influx through voltage-gated Ca2+ channels (VGCCs) is a key signal for
synaptic vesicle release. Synaptic neurexins can partially determine the strength of …

Neurexins constitute a large family of highly variable cell-surface molecules that may
function in synaptic transmission and/or synapse formation. Each of the three known …

Action potential-evoked neurotransmitter release is impaired in knock-out neurons lacking
synaptic cell-adhesion molecules α-neurexins (αNrxns), the extracellularly longer variants of …

Synaptic cell-adhesion molecules and their interactions with other molecular pathways affect
both synapse formation and its function (Varoqueaux et al., 2006; Sudhof, 2008; Bemben et …

To achieve ultrafast neurotransmission, neurons assemble synapses with highly organized
presynaptic and postsynaptic nanomachines that are aligned by synaptic adhesion …

Summary α-and β-neurexins are presynaptic cell-adhesion molecules implicated in autism
and schizophrenia. We find that, although β-neurexins are expressed at much lower levels …

Classically, neurexins are thought to mediate synaptic connections through trans
interactions with a number of different postsynaptic partners. Neurexins are cleaved by …

Neurexins are recognized as key organizers of synapses that are essential for normal brain
function. However, it is unclear whether neurexins are fundamental building blocks of all …

Neurexins (Nrxs) have emerged as potential determinants of synaptic specificity, but little is
known about their localization at central synapses. Here we show that Nrxs have a …

Presynaptic α-neurexins are highly expressed and more frequently linked to
neuropsychiatric and neurodevelopmental disorders than β-neurexins. However, how …