The Role of Cytokines in the Pathogenesis and Treatment of Alcoholic Liver Disease

GGM Scarlata, C Colaci, M Scarcella, M Dallio… - Diseases, 2024 - mdpi.com
Alcoholic liver disease (ALD) is a major cause of chronic liver disease. This term covers a
broad spectrum of liver lesions, from simple steatosis to alcoholic hepatitis and cirrhosis. The …

Alcoholic liver disease: role of cytokines

MG Neuman, Y Maor, RM Nanau, E Melzer, H Mell… - Biomolecules, 2015 - mdpi.com
The present review spans a broad spectrum of topics dealing with alcoholic liver disease
(ALD), including clinical and translational research. It focuses on the role of the immune …

Immunity and inflammatory signaling in alcoholic liver disease

P Mandrekar, A Ambade - Hepatology international, 2014 - Springer
The pathogenesis of alcoholic liver disease (ALD) is multifactorial and characterized by
steatosis, steatohepatitis and cirrhosis. Several signaling pathways in different liver cell …

Targeting inflammation for the treatment of alcoholic liver disease

MJ Xu, Z Zhou, R Parker, B Gao - Pharmacology & Therapeutics, 2017 - Elsevier
Alcoholic liver disease (ALD) is a leading cause of chronic liver disease with a wide
spectrum of manifestations including simple steatosis to steatohepatitis, cirrhosis, and …

[HTML][HTML] Signalling pathways in alcohol-induced liver inflammation

P Mandrekar, G Szabo - Journal of hepatology, 2009 - Elsevier
The pathogenesis of alcoholic liver injury involves interactions of several intracellular
signalling pathways in different cell types of the liver. Alcohol-induced sensitization of liver …

Alcoholic Liver Disease and Immune Response

KB Adhikari, O Tirosh - The Open Gastroenterology Journal, 2012 - benthamopen.com
The alcoholic liver disease (ALD) continues to be a major health problem worldwide with
respect to both mor-bidity and mortality. It is usually an outcome of excessive alcohol …

Ambiguous Pathogenic Roles of Macrophages in Alcohol-Associated Liver Diseases

Y Ait Ahmed, F Lafdil, F Tacke - Hepatic Medicine: Evidence and …, 2023 - Taylor & Francis
Alcohol-associated liver disease (ALD) represents a major public health issue worldwide
and is a leading etiology of liver cirrhosis. Alcohol-related liver injuries include a range of …

Inflammation in alcohol-associated liver disease progression

S Lotersztajn, A Riva, S Wang, S Dooley… - Zeitschrift für …, 2022 - thieme-connect.com
Chronic alcohol consumption induces stress and damage in alcohol metabolising
hepatocytes, which leads to inflammatory and fibrogenic responses. Besides these direct …

Inflammation in alcohol-associated hepatitis: pathogenesis and therapeutic targets

D Feng, S Hwang, A Guillot, Y Wang, Y Guan… - Cellular and Molecular …, 2024 - Elsevier
Alcohol-associated hepatitis (AH) is an acute-on-chronic liver injury that occurs in patients
with chronic alcohol-associated liver disease (ALD). Patients with severe AH have high short …

Key events participating in the pathogenesis of alcoholic liver disease

F Magdaleno, CC Blajszczak, N Nieto - Biomolecules, 2017 - mdpi.com
Alcoholic liver disease (ALD) is a leading cause of morbidity and mortality worldwide. It
ranges from fatty liver to steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma. The …