Nucleic acid delivery by viral and non-viral methods has been a cornerstone for the
contemporary gene therapy aimed at correcting the defective genes, replacing of the …

Successful gene therapy requires the development of an efficient intracellular nucleic acid
delivery system. Cycloamylose (CA) is a large-ring cyclodextrin that has the potential to be …

Cycloamylose (CA) can entrap molecules to form inclusion complexes. Here, we report the
potential application of enzymatically produced CA from low-cost tapioca starch as a …

Cycloamylose (CA) exhibits differences in geometry and greater colloidal stability compared
with amylose. Here we report the synthesis of a cationic CA derivative and its application for …

A new siRNA delivery system made of a functional cycloamylose nanogel is reported.
Cholesterol-bearing cationic cycloamylose formed nanogels by self-assembly in water. The …

Introduction: Active pharmaceutical ingredients (APIs) are evolving from low-molecular-
weight drugs to peptide-, protein-, gene-, oligonucleotide-and cell-based drugs. Therefore …

Considerable research is focused on the development of non-viral vectors for gene and
RNA interference therapies, with significant advancements in this field over the past number …

The aim of this contribution is to summarize recent findings on the potential use of
cyclodextrins and their derivatives as carriers for oligonucleotide agents. Their peculiar …

Cyclodextrin-containing polymers are now being explored as vehicles for delivering nucleic
acids into cells. The structures of the cyclodextrin-containing polycations affect the nucleic …

Introduction: The discovery of synthetic small interfering RNA (siRNA) has led to a surge of
interest in harnessing RNA interference (RNAi) technology for biomedical applications and …