Structure and transcription of integrated HPV DNA in vulvar carcinomas

A Van Arsdale, L Turker, YC Chang, J Gould… - npj Genomic …, 2024 - nature.com
HPV infections are associated with a fraction of vulvar cancers. Through hybridization
capture and DNA sequencing, HPV DNA was detected in five of thirteen vulvar cancers …

Genomic characterization of viral integration sites in HPV‐related cancers

C Bodelon, ME Untereiner, MJ Machiela… - … journal of cancer, 2016 - Wiley Online Library
Persistent infection with carcinogenic human papillomaviruses (HPV) causes the majority of
anogenital cancers and a subset of head and neck cancers. The HPV genome is frequently …

Whole genome sequencing reveals complexity in both HPV sequences present and HPV integrations in HPV-positive oropharyngeal squamous cell carcinomas

G Gao, J Wang, JL Kasperbauer, NM Tombers, F Teng… - BMC cancer, 2019 - Springer
Background High risk human papillomaviruses (HPV) plays important roles in the
development of cervical cancer, a number of other anogenital cancer and they are …

Insertional oncogenesis by HPV70 revealed by multiple genomic analyses in a clinically HPV‐negative cervical cancer

A Van Arsdale, NE Patterson, EC Maggi… - Genes …, 2020 - Wiley Online Library
Cervical carcinogenesis, the second leading cause of cancer death in women worldwide, is
caused by multiple types of human papillomaviruses (HPVs). To investigate a possible role …

Mechanistic signatures of HPV insertions in cervical carcinomas

A Holmes, S Lameiras, E Jeannot, Y Marie… - NPJ genomic …, 2016 - nature.com
To identify new personal biomarkers for the improved diagnosis, prognosis and biological
follow-up of human papillomavirus (HPV)-associated carcinomas, we developed a generic …

Long-read sequencing reveals the structural complexity of genomic integration of HPV DNA in cervical cancer cell lines

Z Wang, C Liu, W Liu, X Lv, T Hu, F Yang, W Yang… - BMC genomics, 2024 - Springer
Background Cervical cancer (CC) causes more than 311,000 deaths annually worldwide.
The integration of human papillomavirus (HPV) is a crucial genetic event that contributes to …

HPV DNA Integration at Actionable Cancer-Related Genes Loci in HPV-Associated Carcinomas

X Sastre-Garau, L Estrada-Virrueta, F Radvanyi - Cancers, 2024 - mdpi.com
Simple Summary In many tumor types, the development of personalized treatments has
been allowed by the optimal molecular characterization of tumor cell genome alterations. In …

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism

Z Hu, D Zhu, W Wang, W Li, W Jia, X Zeng, W Ding… - Nature …, 2015 - nature.com
Human papillomavirus (HPV) integration is a key genetic event in cervical carcinogenesis.
By conducting whole-genome sequencing and high-throughput viral integration detection …

A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques

C Ziegert, N Wentzensen, S Vinokurova, F Kisseljov… - Oncogene, 2003 - nature.com
Persistent infections with high-risk human papillomaviruses (HPVs) induce dysplastic
lesions of the lower genital tract. Some of these lesions eventually progress to invasive …

Simultaneous characterization of somatic events and HPV-18 integration in a metastatic cervical carcinoma patient using DNA and RNA sequencing

WS Liang, J Aldrich, S Nasser, A Kurdoglu… - International Journal of …, 2014 - ijgc.bmj.com
Objective Integration of carcinogenic human papillomaviruses (HPVs) into the host genome
is a significant tumorigenic factor in specific cancers including cervical carcinoma. Although …