Microglia play a pivotal role in brain homeostasis and are essential to protective immunity
within the central nervous system by coordinating the innate immune response to …

Despite recent advances in medicine, viral infections of the central nervous system (CNS)
constitute 20% of diagnosed neurological disorders. Left untreated, these infections can …

Microglia are resident innate immune cells of the central nervous system (CNS) that sense
pathogen-associated molecular pattern (PAMPs) and damage associated molecular …

Intracranial (ic) inoculation of susceptible mice with a glial-tropic strain of mouse hepatitis
virus (JHMV), a murine coronavirus, results in an acute encephalomyelitis followed by viral …

Inflammation is an important factor in the pathogenesis of neurodegenerative diseases, such
as Alzheimer's disease or multiple sclerosis, and during microbial infections of the nervous …

The present study examines functional contributions of microglia in host defense,
demyelination, and remyelination following infection of susceptible mice with a neurotropic …

Recent findings have highlighted the role of microglia in orchestrating normal development
and refining neural network connectivity in the healthy CNS. Microglia are not only vital cells …

Symbiotic microbes impact the function and development of the central nervous system
(CNS); however, little is known about the contribution of the microbiota during viral-induced …

Lipopolysaccharide (LPS), the major component of gram-negative bacterial plasma
membranes, is a potent endotoxin that triggers Toll-like receptor 4 (TLR4) dependent …

The activation of astrocytes and microglia is often associated with diseases of the central
nervous system (CNS). Understanding how activation alters the transcriptome of these cells …