The design of human model systems is highly relevant to unveil the underlying mechanisms
of aging and to provide insights on potential interventions to extend human health and life …

Increased life expectancy, due to the rise in life quality and the decline in mortality rates, is
leading to a society in which the population aged 60 and over is growing more rapidly than …

The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the
field of regenerative medicine. In the past few years, iPSCs have been the subject of …

Aging is accompanied by the functional decline of cells, tissues, and organs, as well as a
striking increase in a wide range of diseases. The reprogramming of somatic cells to …

Advanced age is associated with accumulation of damage and other deleterious changes
and a consequential systemic decline of function. This decline affects all organs and …

The ability to reprogram adult somatic cells back to pluripotency presents a powerful tool for
studying cell-fate identity and modeling human disease. However, the reversal of cellular …

Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …

Induced pluripotent stem cells (IPSCs), with their unlimited regenerative capacity, carry the
promise for tissue replacement to counter age‐related decline. However, attempts to realize …

A global aging population, normally accompanied by a high incidence of aging-associated
diseases, has prompted a renewed interest in basic research on human aging. Although …

Aging is characterized by irreversible loss of physiological integrity, often accompanied by
an organism's loss of function and increased vulnerability to death. Defects in the …