Abstract Recently, COVID-19, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and its variants, caused> 6 million deaths. Symptoms included respiratory …

Over the past few years, COVID-19 has caused widespread suffering worldwide. There is
great research potential in this domain and it is also necessary. The main objective of this …

The acid sphingomyelinase/ceramide system plays an important role in bacterial and viral
infections. Here, we report that either pharmacological inhibition of acid sphingomyelinase …

SARS-CoV-2 variants such as the delta or omicron variants, with higher transmission rates,
accelerated the global COVID-19 pandemic. Thus, novel therapeutic strategies need to be …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic with severe consequences for afflicted individuals and the society as a whole …

Acid Sphingomyelinase (ASM) is a human phosphodiesterase that catalyzes the metabolism
of sphingomyelin (SM) to ceramide and phosphocholine. ASM is involved in the plasma …

In the last 2 years, different pharmacological agents have been indicated as potential
inhibitors of SARS‐CoV‐2 in vitro. Specifically, drugs termed as functional inhibitors of acid …

ABSTRACT The Coronavirus Disease 2019 (COVID-19) pandemic caused by the Severe
Acute Respiratory Syndrome Related Coronavirus 2 (SARS-CoV-2) is a global health …

Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide,
which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS …

The SARS-CoV-2 outbreak is characterized by the need of the search for curative drugs for
treatment. In this paper, we present an update of knowledge about the interest of the …