Multi-omics reveals that 5-O-methylvisammioside prevention acute liver injury in mice by regulating the TNF/MAPK/NF-κB/arachidonic acid pathway

T Zhang, Y Zhong, Y Shi, C Feng, L Xu, Z Chen, X Sun… - Phytomedicine, 2024 - Elsevier
Background The pathogenesis of acute liver injury (ALI) has been a pressing issue in the
medical scientific community. We previously found that 5-O-methylvisammioside (MeV) from …

[HTML][HTML] Veronica persica ameliorates acetaminophen-induced murine hepatotoxicity via attenuating oxidative stress and inflammation

W Tian, J Zhao, MK Kim, HJ Tae, IS Kim, D Ahn… - Biomedicine & …, 2023 - Elsevier
Excess acetaminophen (APAP) commonly causes severe acute liver injury (ALI),
characterized by oxidative stress, pro-inflammatory responses, and hepatocyte damage …

Maltol improves APAP-induced hepatotoxicity by inhibiting oxidative stress and inflammation response via NF-κB and PI3K/Akt signal pathways

Z Wang, W Hao, J Hu, X Mi, Y Han, S Ren, S Jiang… - Antioxidants, 2019 - mdpi.com
Maltol, a food-flavoring agent and Maillard reaction product formed during the processing of
red ginseng (Panax ginseng, CA Meyer), has been confirmed to exert a hepatoprotective …

The Modulation of Phospho-Extracellular Signal-Regulated Kinase and Phospho-Protein Kinase B Signaling Pathways plus Activity of Macrophage-Stimulating …

FC Liu, HP Yu, HC Lee, CY Chen, CC Liao - International Journal of …, 2024 - mdpi.com
Stachydrine, a prominent bioactive alkaloid derived from Leonurus heterophyllus, is a
significant herb in traditional medicine. It has been noted for its anti-inflammatory and …

Kaempferol sophoroside glucoside mitigates acetaminophen-induced hepatotoxicity: Role of Nrf2/NF-κB and JNK/ASK-1 signaling pathways

GA Mohamed, DS El-Agamy, HM Abdallah, IA Sindi… - Heliyon, 2024 - cell.com
APAP (Acetaminophen)-induced hepatic injury is a major public health threat that requires
continuous searching for new effective therapeutics. KSG (Kaempferol-3-sophoroside-7 …

Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling

A Liu, N Tanaka, L Sun, B Guo, JH Kim… - Chemico-biological …, 2014 - Elsevier
Overdose of acetaminophen (APAP) can cause acute liver injury that is sometimes fatal,
requiring efficient pharmacological intervention. The traditional Chinese herb Bupleurum …

Sesamin Protects against APAP‐Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal …

H Du, S Tong, G Kuang, X Gong… - Journal of …, 2023 - Wiley Online Library
Acetaminophen (APAP) overdose would lead to liver toxicity and even acute liver failure in
severe cases by triggering an inflammatory response and oxidative stress. Sesamin has …

Protective effect of dihydrokaempferol on acetaminophen-induced liver injury by activating the SIRT1 pathway

J Zhang, C Hu, X Li, L Liang, M Zhang… - The American Journal …, 2021 - World Scientific
Acetaminophen (APAP) overdose is the leading cause of acute liver failure (ALF) in the
Western world, with limited treatment opportunities. 3, 5, 7, 4′-Tetrahydroxyflavanone …

[HTML][HTML] Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice

Y Yin, Y Zhang, H Li, Y Zhao, E Cai, H Zhu, P Li… - Biomedicine & …, 2019 - Elsevier
Drug-related hepatotoxicity has become a serious social issue nowadays. Acetaminophen
(APAP) was widely used in clinical treatment, although commonly acknowledged that it is a …

Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress

J Li, J Li, H Fang, H Yang, T Wu, X Shi… - International …, 2022 - Elsevier
Isolongifolene (ISO) has antioxidant, anti-inflammatory, anticancer, and neuroprotective
effects; however, it is unclear whether ISO has a protective effects against liver …