Recent advances in dietary androgen receptor inhibitors

L Ren, T Zhang, J Zhang - Medicinal Research Reviews, 2024 - Wiley Online Library
As a nuclear transcription factor, the androgen receptor (AR) plays a crucial role not only in
normal male sexual differentiation and growth of the prostate, but also in benign prostatic …

[HTML][HTML] An update on plant derived anti-androgens

P Grant, S Ramasamy - International journal of endocrinology and …, 2012 - ncbi.nlm.nih.gov
Anti-androgens are an assorted group of drugs and compounds that reduce the levels or
activity of androgen hormones within the human body. Disease states in which this is …

The effects of dietary factors on the androgen receptor and related cellular factors in prostate cancer

CYF Young, A Jatoi, JF Ward… - Current medicinal …, 2004 - ingentaconnect.com
It has been strongly suggested that androgens and the cognate receptor (AR) may play
important roles in the development and progression of prostate cancer. The AR is a …

Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention

JJ Johnson, DN Syed, Y Suh, CR Heren… - Cancer prevention …, 2010 - AACR
Emerging data are suggesting that estrogens, in addition to androgens, may also be
contributing to the development of prostate cancer (PCa). In view of this notion, agents that …

Resveratrol down-regulates the androgen receptor at the post-translational level in prostate cancer cells

N Harada, Y Murata, R Yamaji, T Miura… - Journal of nutritional …, 2007 - jstage.jst.go.jp
Androgen receptor (AR) functions as a transcriptional factor for the development and
progression of prostate cancer. Resveratrol is known to inhibit the function of AR and to …

[HTML][HTML] Natural compounds in prostate cancer prevention and treatment: mechanisms of action and molecular targets

F Fontana, M Raimondi, M Marzagalli, A Di Domizio… - Cells, 2020 - mdpi.com
Prostate cancer (PCa) represents a major cause of cancer mortality among men in
developed countries. Patients with recurrent disease initially respond to androgen …

Oriental herbs as a source of novel anti-androgen and prostate cancer chemopreventive agents

J Lü, SH Kim, C Jiang, HJ Lee, J Guo - Acta Pharmacologica Sinica, 2007 - nature.com
Androgen and androgen receptor (AR) signaling are crucial for the genesis of prostate
cancer (PCa), which can often develop into androgen-ligand-independent diseases that are …

Androgen receptor in human health: a potential therapeutic target

H Rahman Siddique, S Nanda, A Parray… - Current drug …, 2012 - ingentaconnect.com
Androgen is a key for the activation of Androgen Receptor (AR) in most of the disease
conditions, however androgen-independent activation of AR is also found in aggressive type …

The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate …

M Maggiolini, A Vivacqua, A Carpino, D Bonofiglio… - Molecular …, 2002 - ASPET
High consumption of soybean products, such as phytoestrogens, has been hypothesized to
contribute to a reduced incidence of prostate cancer in Southeast Asian people, although …

Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells

SH Mitchell, W Zhu, CYF Young - Cancer Research, 1999 - AACR
Androgens via their receptor (AR) may play a role in prostate cancer etiology. This study
focuses on the inhibitory effects of resveratrol on androgen action in the LNCaP prostate …