Background: Matrine, an alkaloid derived from the dried roots of Sophora flavescens Aiton,
has been utilized for the treatment of liver diseases, but its potential hepatotoxicity raises …

Matrine, an alkaloid isolated from Sophora flavescens, possesses a wide range of
pharmacological properties. However, the use of matrine in clinical practice is limited due to …

Matrine is a bioactive component of the traditional Chinese medical herb Sophora
flavescens that has been used in China to treat various kinds of diseases including virus …

Previous studies by our group demonstrated that radix Sophorae tonkinensis could induce
hepatotoxicity. However, it remains unclear which components of this herb may be …

Background Endoplasmic reticulum (ER) stress, which can promote lipid metabolism
disorders and steatohepatitis, contributes significantly to the pathogenesis of nonalcoholic …

Objective To compare the hepatotoxicity of matrine (MT) and oxymatrine (OMT) and explore
the severity and characteristics of their toxicity, and to preliminarily elucidate their toxic …

Matrine (Mat), a component extracted from Sophora flavescens Ait, has a wide spectrum of
pharmacological effects. Glycyrrhizin (Gly), a major active constituent of licorice (Glycyrrhiza …

Matrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs,
such as Sophora flavescens and Radix Sophorae tonkinensis. Emerging evidence suggests …

Background The pathogenesis of acute liver injury (ALI) has been a pressing issue in the
medical scientific community. We previously found that 5-O-methylvisammioside (MeV) from …

Drug‐induced liver injury (DILI) has become a significant health care problem worldwide.
Centella asiatica (L.) urban was traditionally used to prevent or treat various diseases, yet …