Self-assembly circular multi-DNA mediated rolling circle amplification for sensitive detection of PD-L1+ circulating tumor cells in the peripheral blood of cancer patients

T Ren, D Chen, G Sun, Z Wu, S Wang, Z Cui, X Tian… - Microchemical …, 2024 - Elsevier
It has been found that evaluating the status of programmed cell death ligand (PD-L1) in the
circulating tumor cells (CTCs) was associated with improved efficacy to anti-PD-L1 …

Combination of immunomagnetic separation with aptamer-mediated double rolling circle amplification for highly sensitive circulating tumor cell detection

S Sun, S Yang, X Hu, C Zheng, H Song, L Wang… - ACS …, 2020 - ACS Publications
Breast cancer is the most frequently diagnosed cancer among women, and the circulating
tumor cell (CTC)-meditated distant metastasis is the leading cause of death. Thus, the …

Cascade signal amplification for sensitive detection of cancer cell based on self-assembly of DNA scaffold and rolling circle amplification

Y Li, Y Zeng, X Ji, X Li, R Ren - Sensors and Actuators B: Chemical, 2012 - Elsevier
Combined with a DNA aptamer recognition element, a cascade signal amplification strategy
for sensitive detection of cancer cell has been developed by coupling target triggered self …

Colorimetric assay of rare disseminated tumor cells in real sample by aptamer-induced rolling circle amplification on cell surface

L Xu, Z Jiang, Y Mu, Y Zhang, Q Zhan, J Cui… - Sensors and Actuators B …, 2018 - Elsevier
The identification of tumor cells disseminating in body fluids plays a critical role in the
accurate diagnosis of cancer. Herein, a simple and pragmatic colorimetric strategy has been …

A novel specific and ultrasensitive method detecting extracellular vesicles secreted from lung cancer by padlock probe-based exponential rolling circle amplification

L He, X Yu, R Huang, L Jin, Y Liu, Y Deng, S Li… - Nano Today, 2022 - Elsevier
Lung cancer is one of the most common cancers in the world. Early diagnosis of lung cancer
usually shows promising rate of survival. However, the detection of lung cancer faces great …

In situ signal amplification improves the capture efficiency of circulating tumor cells with low expression of EpCAM

K Chen, Z Zhang, X Zhu, Z Lin, J Xie, Q Dong, Q Fu… - Analytica Chimica …, 2022 - Elsevier
Circulating tumor cells (CTCs) as non-invasive biomarkers have great potential in evaluating
tumor progression and prognosis. However, effective enrichment of CTCs and minimizing …

Immunomagnetic antibody plus aptamer pseudo-DNA nanocatenane followed by rolling circle amplication for highly-sensitive CTC detection

J Wang, H Dong, Y Zhou, L Han, T Zhang, M Lin… - Biosensors and …, 2018 - Elsevier
Biosensing and detecting the rare circulating tumor cells (CTCs) in complex blood samples
are a great challenge but necessary for cancer metastasis prevention. Here we show a …

Reliable detection of extracellular PD-L1 by DNA computation-mediated microfluidics

Y Zhang, Q Wu, Y Huang, W Wang, Y Lu… - Analytical …, 2023 - ACS Publications
Extracellular vesicle PD-L1 (programmed death-1 ligand 1) is of greater value in tumor
diagnosis, prognosis, and efficacy monitoring of anti-PD-1/PD-L1 immunotherapy. However …

Rolling circle amplification combined with gold nanoparticles-tag for ultra sensitive and specific quantification of DNA by inductively coupled plasma mass …

Y He, D Chen, M Li, L Fang, WJ Yang, LJ Xu… - Biosensors and …, 2014 - Elsevier
A novel method for the ultra specific and sensitive detection of DNA in biological samples
was described in this paper based on magnetic beads (MBs)-based rolling circle …

Rolling circle amplification combined with nanoparticle aggregates for highly sensitive identification of DNA and cancercells

C Ding, N Wang, J Zhang, Z Wang - Biosensors and Bioelectronics, 2013 - Elsevier
An electrochemical biosensor based on rolling circle amplification (RCA) and nanoparticle
aggregates for highly sensitive identification of DNA and cancer cells were established in …