Cytotoxic rhamnolipid micelles drive acute virulence in Pseudomonas aeruginosa

Q Xu, D Kang, MD Meyer, CL Pennington… - Infection and …, 2024 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic human pathogen that has developed multi-or
even pan-drug resistance toward most frontline and last resort antibiotics, leading to …

Inhibition of Macrophage Phagocytosis by Pseudomonas aeruginosa Rhamnolipids In Vitro and In Vivo

CD McClure, NL Schiller - Current microbiology, 1996 - Springer
Patients with cystic fibrosis often have chronic and ultimately lethal pulmonary infections with
Pseudomonas aeruginosa. In order to understand why these bacteria resist pulmonary …

Pseudomonas aeruginosa‐derived rhamnolipids subvert the host innate immune response through manipulation of the human beta‐defensin‐2 expression

J Dössel, U Meyer‐Hoffert, JM Schröder… - Cellular …, 2012 - Wiley Online Library
Pseudomonas aeruginosa is a well‐known cause of infections especially in compromised
patients. To neutralize this pathogen, the expression of antimicrobial factors in epithelial …

Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

M Van Gennip, LD Christensen, M Alhede, R Phipps… - Apmis, 2009 - Wiley Online Library
Many of the virulence factors produced by the opportunistic human pathogen Pseudomonas
aeruginosa are quorum‐sensing (QS) regulated. Among these are rhamnolipids, which …

A new assay for rhamnolipid detection—important virulence factors of Pseudomonas aeruginosa

M Laabei, WD Jamieson, SE Lewis, SP Diggle… - Applied microbiology …, 2014 - Springer
Rhamnolipids (RLs) are heterogeneous glycolipid molecules that are composed of one or
two l-rhamnose sugars and one or two β-hydroxy fatty acids, which can vary in their length …

Rhamnolipids Are Virulence Factors That Promote Early Infiltration of Primary Human Airway Epithelia by Pseudomonas aeruginosa

L Zulianello, C Canard, T Köhler, D Caille… - Infection and …, 2006 - Am Soc Microbiol
The opportunistic bacterium Pseudomonas aeruginosa causes chronic respiratory infections
in cystic fibrosis and immunocompromised individuals. Bacterial adherence to the …

Pseudomonas aeruginosa biofilms: mechanisms of immune evasion

M Alhede, T Bjarnsholt, M Givskov, M Alhede - Advances in applied …, 2014 - Elsevier
The opportunistic gram-negative bacterium Pseudomonas aeruginosa is implicated in many
chronic infections and is readily isolated from chronic wounds, medical devices, and the …

[引用][C] Shielding, a new pathogen defence mechanism against PMNs

P Cornelis - Microbiology, 2009 - microbiologyresearch.org
In an article published in this issue, Alhede et al.(2009) demonstrate that the opportunistic
pathogen Pseudomonas aeruginosa can react to the presence of PMNs by producing …

[HTML][HTML] Pseudomonas aeruginosa rhamnolipid micelles deliver toxic metabolites and antibiotics into Staphylococcus aureus

BG Gdaniec, F Bonini, F Prodon, T Braschler, T Köhler… - IScience, 2022 - cell.com
Efficient delivery of toxic compounds to bacterial competitors is essential during interspecies
microbial warfare. Rhamnolipids (RLPs) are glycolipids produced by Pseudomonas and …

Rhamnolipids mediate an interspecies biofilm dispersal signaling pathway

A Bhattacharjee, TD Nusca, AI Hochbaum - ACS chemical biology, 2016 - ACS Publications
Bacterial biofilms are problematic in natural and anthropogenic environments, and they
confer protective properties on their constituent cells, making them difficult to treat with …