Background Alzheimer's disease (AD) and related Tauopathies are characterised by the
pathologically hyperphosphorylated and aggregated microtubule‐associated protein Tau …

An active role of neuroinflammation and the NLRP3 inflammasome in Alzheimer's disease
and related tauopathies is increasingly identified, supporting NLRP3 as an interesting …

Brains of Alzheimer's disease patients are characterized by the presence of amyloid plaques
and neurofibrillary tangles, both invariably associated with neuroinflammation. A crucial role …

Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation,
driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that …

Activity of the NLRP3 inflammasome promotes tau pathology, a new mouse study published
in Glia has shown. Stancu et al. developed an NLRP3-deficient version of a transgenic …

Activation of the NLRP3 inflammasome in microglia can drive tau pathology in a mouse
model of frontotemporal dementia (FTD), according to a new study published in Nature. The …

In tauopathies, abnormal deposition of intracellular tau protein followed by gradual elevation
of tau in cerebrospinal fluids and neuronal loss has been documented, however, the …

Intra-neuronal misfolding of monomeric tau protein to toxic β-sheet rich neurofibrillary
tangles is a hallmark of Alzheimer's disease (AD). Tau pathology correlates not only with …

Tauopathies are a broad set of neurodegenerative dementias characterized by the
aggregation of Tau protein. Activated microglia and elevated levels of pro-inflammatory …

Alzheimer's disease (AD) is the most common cause of dementia in the general population
and, to date, constitutes a major therapeutic challenge. In the pathogenesis of AD …