Iron is essential to many biological processes but its poor solubility in aerobic environments
restricts its bioavailability. To overcome this limitation, bacteria have evolved a variety of …

Siderophores are conditionally essential metabolites used by microbes for environmental
iron sequestration. Most Streptomyces strains produce hydroxamate-based desferrioxamine …

Desferrioxamines are hydroxamate siderophores widely conserved in both aquatic and soil-
dwelling Actinobacteria. While the genetic and enzymatic bases of siderophore biosynthesis …

Desferrioxamines are a structurally related family of tris-hydroxamate siderophores that form
strong hexadentate complexes with ferric iron. Desferrioxamine B has been used clinically …

This work aimed to undertake the in situ conversion of the terminal amine groups of bacterial
desferrioxamine (DFO) siderophores, including desferrioxamine B (DFOB), to azide groups …

Bacterial genomes are rife with orphan biosynthetic gene clusters (BGCs) associated with
secondary metabolism of unrealized natural product molecules. Often up to a tenth of the …

Streptomycetes are bacteria known for their extraordinary biosynthetic capabilities. Herein,
we describe the genome and metabolome of a particularly talented strain, Streptomyces …

Siderophores play a vital role in the survival of bacteria, as they facilitate the transport of iron
in low-concentration environments. Nature employs a variety of coordinating functional …

Late-stage assembly of the trimeric linear siderophore desferrioxamine B (DFOB) native to
Streptomyces pilosus involves two DesD-catalyzed condensation reactions between one N …

Desferrioxamine siderophores are assembled by the nonribosomal-peptide-synthetase-
independent siderophore (NIS) synthetase enzyme DesD via ATP-dependent iterative …