The basal ganglia (BG) is part of a basic feedback circuit regulating cortical function, such as
voluntary movements control, via their influence on thalamocortical projections. BG …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a progressive
decline in motor functions, such as bradykinesia, caused by the pathological denervation of …

The first model of the basal ganglia (BG) was conceived almost half a century ago. Since
then, extensive research efforts have been carried out to further refine and understand the …

The availability of suitable animal models and the opportunity to record electrophysiologic
data in movement disorder patients undergoing neurosurgical procedures has allowed …

Parkinson's disease (PD) is a neuro-degenerative pathology affecting the basal ganglia, a
set of small subcortical nervous system nuclei. It induces a progressive necrosis of …

Parkinson's disease (PD) symptoms have been collectively ascribed to malfunctioning of
dopamine-related nigro-striatal and cortico-striatal loops. However, some doubts about this …

We review the contributions of biologically constrained computational models to our
understanding of motor and cognitive deficits in Parkinson's disease (PD). The loss of …

Parkinson's disease (PD) is characterized by motor and cognitive dysfunctions, affecting the
motor behaviour. We summarize evidence that the interplay between motor and cognitive …

Parkinson's disease (PD) has been, until recently, mainly defined by the presence of
characteristic motor symptoms, such as rigidity, tremor, bradykinesia/akinesia, and postural …

Background: The substantial heterogeneity of clinical symptoms and lack of reliable
progression markers in Parkinson's disease (PD) present a major challenge in predicting …