IKKα, encoded by CHUK, is crucial in the non-canonical NF-κB pathway and part of the IKK
complex activating the canonical pathway alongside IKKβ. Absence of IKKα cause fetal …

The transcription factor NF-κB plays a key role in numerous physiological processes such as
inflammation, immunity, cell proliferation or control of cell death. Its activation is tightly …

Precise regulation of nuclear factor κB (NF-κB) signaling is crucial for normal immune
responses, and defective NF-κB activity underlies a range of immunodeficiencies. NF-κB is …

Mutations in the IKBKB gene cause severe immunodeficiency, characterized clinically by
persistent respiratory or gastrointestinal infections. Targeted gene panel sequencing …

The kinase IKKα has a well-described activating role in the noncanonical transcription factor
NF-κB pathway. Evidence now suggests that IKKα also inhibits the canonical NF-κB pathway …

Inhibitor of nuclear factor kappa B kinase alpha (IKKα) is critical for p100/NF-κB2
phosphorylation and processing into p52 and activation of the noncanonical NF-κB pathway …

The activation of the I-κB kinase (IKK) complex by TNF or LPS stimulates phosphorylation
and degradation of I-κBα, leading to the nuclear translocation of NF-κB. The IKK complex is …

Signaling regulated by NFκB and related transcription factors is centrally important to many
inflammatory and autoimmune diseases, cancer, and stress responses. The kinase that …

Anhidrotic Ectodermal Dysplasia with ImmunoDeficiency (EDA-ID, OMIM 300291) and
Incontinentia Pigmenti (IP, OMIM 308300) are two rare diseases, caused by mutations of the …

NF-κB signaling is a central pathway of immunity and integrates signal transduction upon a
wide array of inflammatory stimuli. Noncanonical NF-κB signaling is activated by a small …