Inflammatory epithelial diseases are spurred by the concomitant dysregulation of immune
and epithelial cells. How these two dysregulated cellular compartments simultaneously …

Immune cell− derived IL-17A is one of the key pathogenic cytokines in psoriasis, an
immunometabolic disorder. Although IL-17A is an established regulator of cutaneous …

Psoriasis pathology is driven by the type 3 cytokines IL-17 and Il-22, but little is understood
about the dynamics that initiate alterations in tissue homeostasis. Here, we use mouse …

The burgeoning arena of immunometabolism provides evidence of how cellular, as well as
local (tissue)/systemic metabolic pathways, are playing an important role in controlling …

Dysregulated macrophage responses and changes in tissue metabolism are hallmarks of
chronic, sterile inflammation. However, the metabolic cues that direct and support …

In a recent paper published in Science, Konieczny et al. describe that IL-17A produced by
RORγt+ γδ T cells governs wound epithelial cell hypoxic adaptation, which is required for …

Abstract IL-17-producing TH 17 cells have been associated with autoimmune diseases such
as multiple sclerosis (MS), psoriasis, Crohn's disease, and ulcerative colitis (Han et al …

Rationale: Skin cells actively metabolize nutrients to ensure cell proliferation and
differentiation. Psoriasis is an immune-disorder-related skin disease with hyperproliferation …