Diagnostic Challenges and Emerging Pathogeneses of Selected Glomerulopathies

NK Andeen, J Hou - Pediatric and Developmental Pathology, 2024 - journals.sagepub.com
Recent progress in glomerular immune complex and complement-mediated diseases have
refined diagnostic categories and informed mechanistic understanding of disease …

A Guide for Adult Nephrologists and Hematologists to Managing Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy in Teens Transitioning to Young Adults

MR Khursigara, M Matsuda-Abedini… - Advances in Chronic …, 2022 - Elsevier
Atypical hemolytic uremic syndrome and C3 glomerulopathy/immune complex
membranoproliferative glomerulonephritis are ultra-rare chronic, complement-mediated …

Making sense of the spectrum of glomerular disease associated with complement dysregulation

SA Johnson, EKS Wong, CM Taylor - Pediatric Nephrology, 2014 - Springer
Over recent years, complement has emerged as a major player in the development of a
number of glomerular diseases, including atypical haemolytic uraemic syndrome …

C3 Glomerulopathy

M Riedl, P Thorner, C Licht - Pediatric Nephrology, 2017 - Springer
Recent advances in our understanding of the disease pathology of membranoproliferative
glomerulonephritis has resulted in its re-classification as complement C3 glomerulopathy …

[HTML][HTML] Glomerular diseases dependent on complement activation, including atypical hemolytic uremic syndrome, membranoproliferative glomerulonephritis, and C3 …

M Noris, G Remuzzi - American Journal of Kidney Diseases, 2015 - Elsevier
Complement is part of the innate immune system and plays a fundamental role in the
clearance of immune complexes and cell debris. The main effector mechanisms of …

[HTML][HTML] Clinico-pathogenic similarities and differences between infection-related glomerulonephritis and C3 glomerulopathy

Y Wada, M Kamata, R Miyasaka, T Abe… - International Journal of …, 2023 - mdpi.com
Recently, the comprehensive concept of “infection-related glomerulonephritis (IRGN)” has
replaced that of postinfectious glomerulonephritis (PIGN) because of the diverse infection …

Understanding the complement‐mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies

S Lionaki, H Gakiopoulou, JN Boletis - APMIS, 2016 - Wiley Online Library
An enhanced understanding of the role of complement in the pathogenesis of
membranoproliferative glomerulonephritis has led to reclassification of the latter into …

Evolution of immunoglobulin deposition in C3-dominant membranoproliferative glomerulopathy

E Kerns, D Rozansky, ML Troxell - Pediatric Nephrology, 2013 - Springer
Abstract Background Complement 3 glomerulopathy (C3GN) is a newly proposed
subcategory of glomerular disease with features including membranoproliferative …

[HTML][HTML] Pediatric membranous nephropathy: In the novel antigens era

G Huang, F Liu, L Yu, J Wang, J Chen… - Frontiers in …, 2022 - frontiersin.org
Membranous nephropathy (MN) falls within the scope of a glomerular disease. MN exhibits
subepithelial immune-complex deposition and capillary wall thickening which could occur in …

Genetics of immune-mediated glomerular diseases: focus on complement

M Noris, G Remuzzi - Seminars in nephrology, 2017 - Elsevier
The spectrum of immune-mediated glomerular diseases is wide, ranging from rare diseases
with well-recognized genetic origins to more common and multifactorial diseases. Immune …