Insights into the Mechanism of Transcription Factors in Pb2+-Induced Apoptosis

J Guo, R Li, Z Ouyang, J Tang, W Zhang, H Chen… - Toxicology, 2024 - Elsevier
The health risks associated with exposure to heavy metals, such as Pb 2+, are increasingly
concerning the public. Pb 2+ can cause significant harm to the human body through …

Lead induces mouse skin fibroblast apoptosis by disrupting intracellular homeostasis

H Wang, H Wang, J Guan, W Guan, Z Liu - Scientific Reports, 2023 - nature.com
Lead (Pb) is a critical industrial and environmental contaminant that can cause
pathophysiological changes in several cellular and organ systems and their processes …

Lead exposure induces neuronal apoptosis via NFκB p65/RBBP4/Survivin signaling pathway

H Chen, W Zhang, S Luo, Y Li, Q Zhu, Y Xia, H Tan… - Toxicology, 2023 - Elsevier
Lead (Pb), as a heavy metal that is easily exposed in daily life, can cause damage to various
systems of body. Apoptosis is an autonomous cell death process regulated by genes in …

[PDF][PDF] Cadmium and apoptosis: a molecular approach

K Shagirtha, S Miltonprabu - Research & Reviews: A Journal of …, 2016 - researchgate.net
Apoptosis, also known as programmed cell death is a highly regulated and fundamental
process found in all multicellular organisms. It is not only implicated in regulatory …

Endoplasmic reticulum stress and apoptosis triggered by sub-chronic lead exposure in mice spleen: a histopathological study

G Corsetti, C Romano, A Stacchiotti, E Pasini… - … Trace Element Research, 2017 - Springer
Lead (Pb) is an environmental oncogenic metal that induces immunotoxicity and anaemia.
Emerging evidence has linked Pb toxicity with endoplasmic reticulum-driven apoptosis and …

From ferroptosis to cuproptosis, and calcicoptosis, to find more novel metals-mediated distinct form of regulated cell death

J Gu, C Guo, J Ruan, K Li, Y Zhou, X Gong, H Shi - Apoptosis, 2024 - Springer
Regulated cell death (RCD), also known as programmed cell death (PCD), plays a critical
role in various biological processes, such as tissue injury/repair, development, and …

Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases

K Sahoo, A Sharma - Apoptosis, 2023 - Springer
Ferroptosis is a new type of iron-dependent cell death induced by a failure of the lipid repair
protein GPX4 or the Xc-antiporter, which is essential for glutathione production. Some heavy …

PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway

T Luo, Y Yuan, Q Yu, G Liu, M Long, K Zhang, J Bian… - Scientific reports, 2017 - nature.com
Parthanatos is a newly discovered form of PARP-1-dependent programmed cell death. It has
been reported to play an important role in several cancer or tumour cells; however, few …

Signal transduction associated with lead-induced neurological disorders: A review

Y Fang, L Lu, Y Liang, D Peng, M Aschner… - Food and Chemical …, 2021 - Elsevier
Lead is a heavy metal pollutant that is widely present in the environment. It affects every
organ system, yet the nervous system appears to be the most sensitive and primary target …

Lead toxicity induces autophagy to protect against cell death through mTORC1 pathway in cardiofibroblasts

L Sui, RH Zhang, P Zhang, KL Yun… - Bioscience …, 2015 - portlandpress.com
Heavy metals, such as lead (Pb2+), are usually accumulated in human bodies and impair
human's health. Lead is a metal with many recognized adverse health side effects and yet …