The EGFR-RAS-ERK pathway is one of the most important signaling cascades in cell
survival, growth, and proliferation. Aberrant activation of this pathway is a common …

Abstract Epigallocatechin-3-gallate (EGCG), a major polyphenol component of green tea,
presents anticancer efficacy. However, its exact mechanism of action is not known. In this …

At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp).
Inhibitors targeting various effectors within the ERKp have been developed and explored for …

ERK1 and ERK5 are proposed to have pivotal roles in several types of cancer. Under some
circumstance, ERK5 may provide a common bypass route, which rescues proliferation upon …

As a critical signaling node, ERK1/2 are attractive drug targets, particularly in tumors driven
by activation of the MAPK pathway. Utility of targeting the MAPK pathway has been …

Extracellular signal-regulated kinase 3 (ERK3) is an atypical member of the mitogen-
activated protein kinase (MAPK) family, members of which play essential roles in diverse …

Dual EGFR/erbB2 inhibition is an attractive therapeutic strategy for epithelial tumors, as
ligand-induced erbB2/EGFR heterodimerization triggers potent proliferative and survival …

The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAF-MEK-
ERK signal cascade, functions to transmit upstream signals to its downstream effectors to …

The importance of ERK5 kinase signaling in tumorigenicity, metastasis, and drug resistance
of cancer stem cells (CSCs) has been recognized recently, and we report a unique dual …

The oncogenic protein ERK, a member of the extracellular signal-regulated kinase (ERK)
cascade, is a well characterized signaling molecule involved in tumorigenesis. The ERK …