Design and development of 6-hydrazinonicotinyl-fatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent

J González, MF García, P Cabral, V Calzada… - Brazilian Journal of …, 2024 - SciELO Brasil
The goal of this work is to identify new fatty acid-mimetic 99mTc-complexes to be used as
myocardial imaging agents that allow studying heart abnormalities in high-risk patients. In …

Modified “4+ 1” mixed ligand technetium-labeled fatty acids for myocardial imaging: evaluation of myocardial uptake and biodistribution

P Mirtschink, SN Stehr, HJ Pietzsch… - Bioconjugate …, 2008 - ACS Publications
Our group previously synthesized 99mTc-labeled fatty acids suitable for myocardial
metabolism and flow imaging. In this set of experiments, 29 new analogues were …

Synthesis and bio-evaluation of a new fatty acid derivative for myocardial imaging

A Mathur, S Subramanian, MB Mallia… - Bioorganic & medicinal …, 2008 - Elsevier
Development of a 99mTc-fatty acid analogue is of interest, as 99mTc is logistically
advantageous over the cyclotron-produced 11C and 123I. Synthesis of a 16 carbon fatty …

Syntheses and biological evaluation of 99m Tc-HYNIC-fatty acid complexes for myocardial imaging

A Mathur, AK Sharma, VV Murhekar, MB Mallia… - RSC …, 2015 - pubs.rsc.org
The aim of the present study is to identify a 99mTc-labeled fatty acid tracer which could be a
possible substitute of the widely used 123I-labeled fatty acids in studying myocardial …

Synthesis and Biological Evaluation of a New Type of 99mTechnetium-Labeled Fatty Acid for Myocardial Metabolism Imaging

M Walther, CM Jung, R Bergmann… - Bioconjugate …, 2007 - ACS Publications
Technetium-labeled fatty acids intended for myocardial metabolism imaging and the
respective rhenium model complexes were synthesized according to the “4+ 1” mixed-ligand …

Design of bifunctional radiopharmaceutical for the development of 99mTc complexes for myocardial imaging agents

T Hosotani, A Yokoyama, Y Arano, K Horiuchi… - International Journal of …, 1986 - Elsevier
Several bifunctional radiopharmaceuticals (BR), molecules containing a neutral 99m Tc-
dithiosemicarbazone (DTS) structure as a chelating site, along with a functional amino group …

6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for 99mTc-Labeling of Small Biomolecules

S Liu - … Agents III: Radiopharmaceuticals–From Diagnostics to …, 2005 - Springer
Abstract 99m Tc-labeled small biomolecules are a class of receptor-based, target specific
radiopharmaceuticals for the detection of various diseases, such as cancer, thrombosis …

A Novel Ternary Ligand System for 99mTc-Labeling of Hydrazino Nicotinamide-Modified Biologically Active Molecules Using Imine-N-Containing Heterocycles as …

S Liu, DS Edwards, AR Harris - Bioconjugate chemistry, 1998 - ACS Publications
A hydrazinonicotinamide-functionalized cyclic platelet glycoprotein IIb/IIIa (GPIIb/IIIa)
receptor antagonist [HYNICtide, cyclo (d-Val-NMeArg-Gly-Asp-Mamb (5-(6-(6 …

Preparation, characterization and biodistribution of a new technetium‐99 m nitrido complex with 2‐methoxyisobutylisonitrile and comparison with 99mTc–MIBI

XZ Zhang, XB Wang, F Jia, ZG Tang… - Journal of Labelled …, 2002 - Wiley Online Library
The preparation of complex 99mTcN–MIBI was carried out using two alternative procedures
that led to the formation of the complex with high radiochemical purity (> 90%). The partition …

Novel ether-containing ligands as potential 99mtechnetium (I) heart agents

KP Maresca, JF Kronauge, J Zubieta… - Inorganic Chemistry …, 2007 - Elsevier
A novel pair of lipophilic cationic technetium complexes utilizing the 99mTc-tricarbonyl core
have been developed and evaluated for cardiac uptake. Di-(pyridyl-2-methyl) amine (DPA) …