Design and development of 6-hydrazinonicotinyl-fatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent
The goal of this work is to identify new fatty acid-mimetic 99mTc-complexes to be used as
myocardial imaging agents that allow studying heart abnormalities in high-risk patients. In …
myocardial imaging agents that allow studying heart abnormalities in high-risk patients. In …
Modified “4+ 1” mixed ligand technetium-labeled fatty acids for myocardial imaging: evaluation of myocardial uptake and biodistribution
P Mirtschink, SN Stehr, HJ Pietzsch… - Bioconjugate …, 2008 - ACS Publications
Our group previously synthesized 99mTc-labeled fatty acids suitable for myocardial
metabolism and flow imaging. In this set of experiments, 29 new analogues were …
metabolism and flow imaging. In this set of experiments, 29 new analogues were …
Synthesis and bio-evaluation of a new fatty acid derivative for myocardial imaging
A Mathur, S Subramanian, MB Mallia… - Bioorganic & medicinal …, 2008 - Elsevier
Development of a 99mTc-fatty acid analogue is of interest, as 99mTc is logistically
advantageous over the cyclotron-produced 11C and 123I. Synthesis of a 16 carbon fatty …
advantageous over the cyclotron-produced 11C and 123I. Synthesis of a 16 carbon fatty …
Syntheses and biological evaluation of 99m Tc-HYNIC-fatty acid complexes for myocardial imaging
The aim of the present study is to identify a 99mTc-labeled fatty acid tracer which could be a
possible substitute of the widely used 123I-labeled fatty acids in studying myocardial …
possible substitute of the widely used 123I-labeled fatty acids in studying myocardial …
Synthesis and Biological Evaluation of a New Type of 99mTechnetium-Labeled Fatty Acid for Myocardial Metabolism Imaging
M Walther, CM Jung, R Bergmann… - Bioconjugate …, 2007 - ACS Publications
Technetium-labeled fatty acids intended for myocardial metabolism imaging and the
respective rhenium model complexes were synthesized according to the “4+ 1” mixed-ligand …
respective rhenium model complexes were synthesized according to the “4+ 1” mixed-ligand …
Design of bifunctional radiopharmaceutical for the development of 99mTc complexes for myocardial imaging agents
T Hosotani, A Yokoyama, Y Arano, K Horiuchi… - International Journal of …, 1986 - Elsevier
Several bifunctional radiopharmaceuticals (BR), molecules containing a neutral 99m Tc-
dithiosemicarbazone (DTS) structure as a chelating site, along with a functional amino group …
dithiosemicarbazone (DTS) structure as a chelating site, along with a functional amino group …
6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for 99mTc-Labeling of Small Biomolecules
S Liu - … Agents III: Radiopharmaceuticals–From Diagnostics to …, 2005 - Springer
Abstract 99m Tc-labeled small biomolecules are a class of receptor-based, target specific
radiopharmaceuticals for the detection of various diseases, such as cancer, thrombosis …
radiopharmaceuticals for the detection of various diseases, such as cancer, thrombosis …
A Novel Ternary Ligand System for 99mTc-Labeling of Hydrazino Nicotinamide-Modified Biologically Active Molecules Using Imine-N-Containing Heterocycles as …
S Liu, DS Edwards, AR Harris - Bioconjugate chemistry, 1998 - ACS Publications
A hydrazinonicotinamide-functionalized cyclic platelet glycoprotein IIb/IIIa (GPIIb/IIIa)
receptor antagonist [HYNICtide, cyclo (d-Val-NMeArg-Gly-Asp-Mamb (5-(6-(6 …
receptor antagonist [HYNICtide, cyclo (d-Val-NMeArg-Gly-Asp-Mamb (5-(6-(6 …
Preparation, characterization and biodistribution of a new technetium‐99 m nitrido complex with 2‐methoxyisobutylisonitrile and comparison with 99mTc–MIBI
XZ Zhang, XB Wang, F Jia, ZG Tang… - Journal of Labelled …, 2002 - Wiley Online Library
The preparation of complex 99mTcN–MIBI was carried out using two alternative procedures
that led to the formation of the complex with high radiochemical purity (> 90%). The partition …
that led to the formation of the complex with high radiochemical purity (> 90%). The partition …
Novel ether-containing ligands as potential 99mtechnetium (I) heart agents
KP Maresca, JF Kronauge, J Zubieta… - Inorganic Chemistry …, 2007 - Elsevier
A novel pair of lipophilic cationic technetium complexes utilizing the 99mTc-tricarbonyl core
have been developed and evaluated for cardiac uptake. Di-(pyridyl-2-methyl) amine (DPA) …
have been developed and evaluated for cardiac uptake. Di-(pyridyl-2-methyl) amine (DPA) …
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