Immune responses to human fungal pathogens and therapeutic prospects

MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

[HTML][HTML] Antifungal drug-resistance mechanisms in Candida biofilms

J Kaur, CJ Nobile - Current opinion in microbiology, 2023 - Elsevier
Highlights•Few classes of antifungal drugs currently exist to treat fungal infections.•Infections
caused by Candida biofilms can be resistant to known antifungal drugs.•Growth in the …

Invasive candidiasis

C Lass-Flörl, SS Kanj, NP Govender… - Nature Reviews …, 2024 - nature.com
Invasive candidiasis is an important fungal disease caused by Candida albicans and,
increasingly, non-albicans Candida pathogens. Invasive Candida infections originate most …

DSF-family quorum sensing signal-mediated intraspecies, interspecies, and inter-kingdom communication

YW He, Y Deng, Y Miao, S Chatterjee, TM Tran… - Trends in …, 2023 - cell.com
While most bacteria are unicellular microbes they communicate with each other and with
their environments to adapt their behaviors. Quorum sensing (QS) is one of the best-studied …

Virulence Factors of Candida spp. and Host Immune Response Important in the Pathogenesis of Vulvovaginal Candidiasis

P Czechowicz, J Nowicka, G Gościniak - International journal of molecular …, 2022 - mdpi.com
Vulvovaginal candidiasis (VVC) is one of the most common types of vaginal infections in
women around the world and is often underestimated by both patients and doctors …

C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

JV Desai, D Kumar, T Freiwald, D Chauss… - Cell, 2023 - cell.com
Systemic candidiasis is a common, high-mortality, nosocomial fungal infection.
Unexpectedly, it has emerged as a complication of anti-complement C5-targeted …

The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates filamentation, biofilm formation, and …

VE Glazier, J Kramara, T Ollinger, NV Solis… - MBio, 2023 - Am Soc Microbiol
Candida albicans is a diploid human fungal pathogen that displays significant genomic and
phenotypic heterogeneity over a range of virulence traits and in the context of a variety of …

The Interplay between Candida albicans, Vaginal Mucosa, Host Immunity and Resident Microbiota in Health and Disease: An Overview and Future Perspectives

R Gaziano, S Sabbatini, C Monari - Microorganisms, 2023 - mdpi.com
Vulvovaginal candidiasis (VVC), which is primarily caused by Candida albicans, is an
infection that affects up to 75% of all reproductive-age women worldwide. Recurrent VVC …

We need to talk about Candida tropicalis: Virulence factors and survival mechanisms

MM Dos Santos, K Ishida - Medical mycology, 2023 - academic.oup.com
Candida tropicalis is a notable species of the Candida genus representing an impressive
epidemiology in tropical regions, especially in South America and Asia, where India already …

Intravital imaging-based genetic screen reveals the transcriptional network governing Candida albicans filamentation during mammalian infection

RS Wakade, LC Ristow, M Wellington, DJ Krysan - Elife, 2023 - elifesciences.org
Candida albicans is one of the most common human fungal pathogens. C. albicans
pathogenesis is tightly linked to its ability to under a morphogenetic transition from typically …