Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

Osteoarthritis (OA) is a chronic degenerative disease of diarthrodial joints most commonly
affecting people over the age of forty. The causes of OA are still unknown and there is much …

1. Background Arthritis is a leading cause of pain, disfigurement, and disability in the United
States where nearly one-quarter of all adults have received an affirmative diagnosis. 2 …

Osteoarthritis (OA) is unquestionably one of the most important chronic health issues in
humans, affecting millions of individuals and costing billions of dollars annually. Despite …

Pain is ultimately a perceptual phenomenon. It is built from information gathered by
specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and …

Immunomodulatory drugs can inhibit bacterial growth, yet their mechanism of action,
spectrum, and clinical relevance remain unknown. Methotrexate (MTX), a first-line …

There is a well-established historical observation that structural joint damage by plain X-ray
correlates poorly with symptomatic disease in osteoarthritis (OA). This is often attributed to …

Different subsets and/or polarized phenotypes of monocytes and macrophages may play
distinct roles during the development and resolution of inflammation. Here, we demonstrate …

Osteoarthritis (OA) is a major cause of suffering for millions of people. Investigating the
disease directly on humans may be challenging. The aim of the present study is to …