Reactive oxygen species scavenging nanomedicine for the treatment of ischemic heart disease

Z Zhang, R Dalan, Z Hu, JW Wang… - Advanced …, 2022 - Wiley Online Library
Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

Side effects of statins: from pathophysiology and epidemiology to diagnostic and therapeutic implications

M Ruscica, N Ferri, M Banach, CR Sirtori… - Cardiovascular …, 2022 - academic.oup.com
Abstract Treatment with statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A
reductase, has proven beneficial preventive effects on cardiovascular events. However …

Obesity and dyslipidemia: a review of current evidence

J Vekic, A Stefanovic, A Zeljkovic - Current Obesity Reports, 2023 - Springer
Abstract Purpose of Review Obesity is accompanied by atherogenic dyslipidemia, a specific
lipid disorder characterized by both quantitative and qualitative changes of plasma …

Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review

P Ranasinghe, ML Addison, JW Dear… - British Journal of …, 2023 - Wiley Online Library
Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the
expression of specific genes. RNA interference technology, using synthetic structurally well …

Beyond statins: New pharmacological targets to decrease LDL-cholesterol and cardiovascular events

E Raschi, M Casula, AFG Cicero, A Corsini… - Pharmacology & …, 2023 - Elsevier
The pharmacological treatment of dyslipidemia, a major modifiable risk factor for developing
atherosclerotic cardiovascular disease (ASCVD), remains a debated and controversial …

Statin use and risk of dementia or Alzheimer's disease: a systematic review and meta-analysis of observational studies

E Olmastroni, G Molari, N De Beni… - European journal of …, 2022 - academic.oup.com
Aims As the potential impact of statins on cognitive decline and dementia is still debated, we
conducted a meta-analysis of observational studies to examine the effect of statin use on the …

The association between elevated lipid profile and liver enzymes: a study on Bangladeshi adults

RR Kathak, AH Sumon, NH Molla, M Hasan, R Miah… - Scientific reports, 2022 - nature.com
Dyslipidemia, a major contributor to cardiovascular diseases, is rapidly increasing in Asian
countries including Bangladesh. In addition to the cardiovascular system, abnormal lipid …

Analysis of age-dependent gene-expression in human tissues for studying diabetes comorbidities

PH Guzzi, F Cortese, GC Mannino, E Pedace… - Scientific Reports, 2023 - nature.com
The study of the relationship between type 2 diabetes mellitus (T2DM) disease and other
pathologies (comorbidities), together with patient age variation, poses a challenge for …

Radical oxygen species: an important breakthrough point for botanical drugs to regulate oxidative stress and treat the disorder of glycolipid metabolism

M Luo, Y Zheng, S Tang, L Gu, Y Zhu, R Ying… - Frontiers in …, 2023 - frontiersin.org
Background: The incidence of glycolipid metabolic diseases is extremely high worldwide,
which greatly hinders people's life expectancy and patients' quality of life. Oxidative stress …

A review of cardiovascular effects and underlying mechanisms of legacy and emerging per-and polyfluoroalkyl substances (PFAS)

ZJ Wen, YJ Wei, YF Zhang, YF Zhang - Archives of Toxicology, 2023 - Springer
Cardiovascular disease (CVD) poses the leading threats to human health and life, and their
occurrence and severity are associated with exposure to environmental pollutants. Per-and …