Hydrogel interfaces for merging humans and machines

H Yuk, J Wu, X Zhao - Nature Reviews Materials, 2022 - nature.com
The last few decades have witnessed unprecedented convergence between humans and
machines that closely operate around the human body. Despite these advances, traditional …

Regulation of axonal regeneration after mammalian spinal cord injury

B Zheng, MH Tuszynski - Nature Reviews Molecular Cell Biology, 2023 - nature.com
One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

A Rowald, S Komi, R Demesmaeker, E Baaklini… - Nature medicine, 2022 - nature.com
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …

[HTML][HTML] Walking naturally after spinal cord injury using a brain–spine interface

H Lorach, A Galvez, V Spagnolo, F Martel, S Karakas… - Nature, 2023 - nature.com
A spinal cord injury interrupts the communication between the brain and the region of the
spinal cord that produces walking, leading to paralysis,. Here, we restored this …

Natural and targeted circuit reorganization after spinal cord injury

MA Anderson, JW Squair, M Gautier, TH Hutson… - Nature …, 2022 - nature.com
A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …

Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery

K Xi, Y Gu, J Tang, H Chen, Y Xu, L Wu, F Cai… - Nature …, 2020 - nature.com
The strategies concerning modification of the complex immune pathological inflammatory
environment during acute spinal cord injury remain oversimplified and superficial. Inspired …

A tissue‐like soft all‐hydrogel battery

T Ye, J Wang, Y Jiao, L Li, E He, L Wang… - Advanced …, 2022 - Wiley Online Library
To develop wearable and implantable bioelectronics accommodating the dynamic and
uneven biological tissues and reducing undesired immune responses, it is critical to adopt …

[HTML][HTML] Dissecting the dual role of the glial scar and scar-forming astrocytes in spinal cord injury

T Yang, YJ Dai, G Chen, SS Cui - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Recovery from spinal cord injury (SCI) remains an unsolved problem. As a major component
of the SCI lesion, the glial scar is primarily composed of scar-forming astrocytes and plays a …

Cooperative assembly of a designer peptide and silk fibroin into hybrid nanofiber gels for neural regeneration after spinal cord injury

F Feng, X Song, Z Tan, Y Tu, L Xiao, P Xie, Y Ma… - Science …, 2023 - science.org
Local reconstruction of a permissive environment with biomaterials is a promising strategy to
treat spinal cord injury (SCI). We reported a hybrid hydrogel fabricated from a small …

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

KJE Matson, DE Russ, C Kathe, I Hua, D Maric… - Nature …, 2022 - nature.com
After spinal cord injury, tissue distal to the lesion contains undamaged cells that could
support or augment recovery. Targeting these cells requires a clearer understanding of their …