Hydrogel interfaces for merging humans and machines
The last few decades have witnessed unprecedented convergence between humans and
machines that closely operate around the human body. Despite these advances, traditional …
machines that closely operate around the human body. Despite these advances, traditional …
Regulation of axonal regeneration after mammalian spinal cord injury
B Zheng, MH Tuszynski - Nature Reviews Molecular Cell Biology, 2023 - nature.com
One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …
[HTML][HTML] Walking naturally after spinal cord injury using a brain–spine interface
H Lorach, A Galvez, V Spagnolo, F Martel, S Karakas… - Nature, 2023 - nature.com
A spinal cord injury interrupts the communication between the brain and the region of the
spinal cord that produces walking, leading to paralysis,. Here, we restored this …
spinal cord that produces walking, leading to paralysis,. Here, we restored this …
Natural and targeted circuit reorganization after spinal cord injury
A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …
cord that regulate neurological functions. The consequences are permanent paralysis, loss …
Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery
K Xi, Y Gu, J Tang, H Chen, Y Xu, L Wu, F Cai… - Nature …, 2020 - nature.com
The strategies concerning modification of the complex immune pathological inflammatory
environment during acute spinal cord injury remain oversimplified and superficial. Inspired …
environment during acute spinal cord injury remain oversimplified and superficial. Inspired …
A tissue‐like soft all‐hydrogel battery
To develop wearable and implantable bioelectronics accommodating the dynamic and
uneven biological tissues and reducing undesired immune responses, it is critical to adopt …
uneven biological tissues and reducing undesired immune responses, it is critical to adopt …
[HTML][HTML] Dissecting the dual role of the glial scar and scar-forming astrocytes in spinal cord injury
T Yang, YJ Dai, G Chen, SS Cui - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Recovery from spinal cord injury (SCI) remains an unsolved problem. As a major component
of the SCI lesion, the glial scar is primarily composed of scar-forming astrocytes and plays a …
of the SCI lesion, the glial scar is primarily composed of scar-forming astrocytes and plays a …
Cooperative assembly of a designer peptide and silk fibroin into hybrid nanofiber gels for neural regeneration after spinal cord injury
F Feng, X Song, Z Tan, Y Tu, L Xiao, P Xie, Y Ma… - Science …, 2023 - science.org
Local reconstruction of a permissive environment with biomaterials is a promising strategy to
treat spinal cord injury (SCI). We reported a hybrid hydrogel fabricated from a small …
treat spinal cord injury (SCI). We reported a hybrid hydrogel fabricated from a small …
Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons
KJE Matson, DE Russ, C Kathe, I Hua, D Maric… - Nature …, 2022 - nature.com
After spinal cord injury, tissue distal to the lesion contains undamaged cells that could
support or augment recovery. Targeting these cells requires a clearer understanding of their …
support or augment recovery. Targeting these cells requires a clearer understanding of their …