The mRNA vaccine revolution: COVID-19 has launched the future of vaccinology
During the COVID-19 pandemic, mRNA (mRNA) vaccines emerged as leading vaccine
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …
[HTML][HTML] Development and applications of viral vectored vaccines to combat zoonotic and emerging public health threats
Vaccination is arguably the most cost-effective preventative measure against infectious
diseases. While vaccines have been successfully developed against certain viruses (eg …
diseases. While vaccines have been successfully developed against certain viruses (eg …
Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines
RP Deering, S Kommareddy, JB Ulmer… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Nucleic acid-based vaccines are being developed as a means to combine the
positive attributes of both live-attenuated and subunit vaccines. Viral vectors and plasmid …
positive attributes of both live-attenuated and subunit vaccines. Viral vectors and plasmid …
Current prospects for mRNA gene delivery
A Yamamoto, M Kormann, J Rosenecker… - European Journal of …, 2009 - Elsevier
Replication-deficient viruses have been used most successfully in the field of gene therapy
because of their high transfection efficiency. However, the risk of insertional mutagenesis …
because of their high transfection efficiency. However, the risk of insertional mutagenesis …
Viral vector-based therapeutic cancer vaccines
C Larocca, J Schlom - The Cancer Journal, 2011 - journals.lww.com
Most viruses are naturally immunogenic and can be engineered to express tumor antigen
transgenes. Moreover, many types of recombinant viruses have been shown to infect …
transgenes. Moreover, many types of recombinant viruses have been shown to infect …
RNA: the new revolution in nucleic acid vaccines
AJ Geall, CW Mandl, JB Ulmer - Seminars in immunology, 2013 - Elsevier
Nucleic acid vaccines have the potential to address issues of safety and effectiveness
sometimes associated with vaccines based on live attenuated viruses and recombinant viral …
sometimes associated with vaccines based on live attenuated viruses and recombinant viral …
Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways
WW Leitner, LN Hwang, MJ Deveer, A Zhou… - Nature medicine, 2003 - nature.com
Cancer vaccines targeting'self'antigens that are expressed at consistently high levels by
tumor cells are potentially useful in immunotherapy, but immunological tolerance may block …
tumor cells are potentially useful in immunotherapy, but immunological tolerance may block …
An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector
S Perri, CE Greer, K Thudium, B Doe, H Legg… - Journal of …, 2003 - Am Soc Microbiol
Alphavirus replicon particle-based vaccine vectors derived from Sindbis virus (SIN), Semliki
Forest virus, and Venezuelan equine encephalitis virus (VEE) have been shown to induce …
Forest virus, and Venezuelan equine encephalitis virus (VEE) have been shown to induce …
[HTML][HTML] Recent advances in the molecular design and delivery technology of mRNA for vaccination against infectious diseases
L Yang, L Tang, M Zhang, C Liu - Frontiers in Immunology, 2022 - frontiersin.org
Vaccines can prevent many millions of illnesses against infectious diseases and save
numerous lives every year. However, traditional vaccines such as inactivated viral and live …
numerous lives every year. However, traditional vaccines such as inactivated viral and live …