The chemokine system is a key player in the functioning of the immune system and a sought-
after target for drug candidates. The number of experimental structures of chemokines in …

The complement receptors C3aR and C5aR1, whose signaling is selectively activated by
anaphylatoxins C3a and C5a, are important regulators of both innate and adaptive immune …

Glioblastoma (GBM) is the most aggressive tumor in the central nervous system and
contains a highly immunosuppressive tumor microenvironment (TME). Tumor-associated …

The CC motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has
emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has …

Cholesterol directs the pathway of ligand-induced G protein-coupled receptor (GPCR) signal
transduction. The GPCR C–C motif chemokine receptor 3 (CCR3) is the principal …

The human CC chemokine receptor 8 (CCR8) is an emerging therapeutic target for cancer
immunotherapy and autoimmune diseases. Understanding the molecular recognition of …

Abstract Hydroxycarboxylic acid receptor 2 (HCAR2) belongs to the family of class AG
protein-coupled receptors with key roles in regulating lipolysis and free fatty acid formation …

Simple Summary Overtraining syndrome (OTS) is the reduction in performance due to
excess training and lack of proper recovery, which can lead to the chronic deprivation of …

Abstract CC chemokine receptor 2 (CCR2), a G protein-coupled receptor, plays a role in
many cancer-related processes such as metastasis formation and immunosuppression …

Vγ9Vδ2 T cells represent a promising cancer therapy platform because the implementation
of allogenic, off-the-shelf product candidates is possible. However, intravenous …