Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …

Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …

Epidermal growth factor receptor (EGFR) is of great significance in mediating cell signaling
transduction and tumor behaviors. Currently, third-generation inhibitors of EGFR, especially …

Targeting VEGFR-2 signaling pathway is well-established as an important approach for the
treatment of solid tumors, particularly renal cancer. Herein, novel indolyl-1, 2, 4-triazole …

Overexpression of the epidermal growth factor receptor (EGFR) has been linked to several
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …

The current study demonstrates the synthesis of coumarin-triazole hybrids 8 (ae) in four
steps starting from substituted salicylaldehyde 1 (ae), and diethyl malonate 2. The …

A series of new 6-[(pyridine-2-yl) oxy]-6, 7-dihydro-5H-imidazo [2, 1-b] thiazines 4a-l and
their benzoannelated derivatives 4m-r was synthesized by the reaction between 3-hydroxy …

Cancer is the world's biggest global health concern. The prevalence and mortality rates of
cancer remain high despite significant progress in cancer therapy. The search for more …

The purpose of this literature review was to systematize data from studies of the biological
activity of 1, 2, 4-triazole derivatives with substituents in positions 4 and 5. The authors set …

Abstract N-Aroyl-1, 2, 4-triazoles TAM and TACl were regioselectively synthesized in
excellent yields through an efficient N-acylation reaction of 3-amino-5-methylsulfanyl-1H-1 …