In addition to determining biological sex, sex hormones are known to influence health and
disease via regulation of immune cell activities and modulation of target-organ susceptibility …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely
targeted therapeutically. Agonist binding triggers NR activation and subsequent degradation …

Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of
prostate cancer. To compare the genomic alteration landscapes of EO-PCA with" …

The classical action of androgen receptor (AR) is to regulate gene transcriptional processes
via AR nuclear translocation, response element binding and recruitment of, or crosstalk with …

The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including the
lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC) …

Abstract More than 30 Curcuma species (Zingiberaceae) are found in Asia, where the
rhizomes of these plants are used as both food and medicine, such as in traditional Chinese …

Androgens stimulate myogenesis, but we do not know what cell types within human skeletal
muscle express the androgen receptor (AR) protein and are the target of androgen action …

Androgen deprivation therapy is the major treatment for advanced prostate cancer (PCa).
However, it is a temporary remission, and the patients almost inevitably develop hormone …

Prostate cancer (PCa) is one of the most common cancers and the second leading cause of
cancer-related death among men worldwide. Despite progresses in early diagnosis and …