Background The association between MHTFR Ala222Val polymorphism and breast cancer
(BC) risk are inconclusive. To derive a more precise estimation of the relationship, a …

Hereditary breast and ovarian cancer syndrome (HBOC) represents 5–10% of all patients
with breast cancer and is associated with high-risk pathogenic alleles in BRCA1/2 genes …

The association between oxidative stress and coronary artery disease (CAD) is well
documented. However, the role of epigenetic factors contributing to oxidative stress is …

Elevated homocysteine is a risk factor for many complex disorders. The role of
methylenetetrahydrofolate reductase (MTHFR) gene in methylation of homocysteine makes …

Background Breast cancer is one of the most common malignancies in women and is
associated with a variety of risk factors. The functional single-nucleotide polymorphism …

This systematic review and meta-analysis were conducted to investigate the association
between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms …

Single-nucleotide polymorphisms (SNPs) within genes of the one-carbon metabolism
pathway have been shown to interact with dietary folate intake to modify breast cancer (BC) …

We have earlier demonstrated the role of aberrant one‐carbon metabolism in the etiology of
breast cancer. In the current study, we examine the clinical utility of these factors in …

Polymorphisms in genes encoding enzymes of folate metabolism are a focus of breast
cancer risk studies due of the role of these enzymes in DNA methylation, synthesis, and …

Our recent study showing association of hyperhomocysteinemia and hypomethioninemia in
breast cancer and other studies indicating association of hyperhomocysteinemia with …