Complex diseases such as neurodegenerative disorders and cancer constitute a growing
public health problem due to the rising incidence and lack in effective therapies. Since …

The development of new drugs is multidisciplinary and systematic work. High-throughput
techniques based on “-omics” have driven the discovery of biomarkers in diseases and …

Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of
human diseases including cancer. In this line, now it has become evident that ROS …

Background Gastric cancer imposes a substantial global health burden despite its overall
incidence decrease. A broad spectrum of inherited, environmental and infectious factors …

Benzophenanthridine alkaloids are a class of isoquinoline compounds, which are widely
found in the plants of papaveraceae, corydalis, and rutaceae. Biological activities and …

The phytochemicals contribute to the processes of protection and interaction by acting as
antioxidants, anti-mutagens, anticarcinogens, and antimicrobial agents. Among the diverse …

Sanguinarine is a quaternary ammonium benzophenanthine alkaloid found in traditional
herbs such as Chelidonium, Corydalis, Sanguinarum, and Borovula. It has been proven to …

Sanguinarine (SNG), a natural compound with an array of pharmacological activities, has
promising therapeutic potential against a number of pathological conditions, including …

Tripartite motif (TRIM) 31 is a new member of the TRIM family and functions as an E3
ubiquitin ligase. Abnormal TRIM31 expression leads to a variety of pathological conditions …

Hepatocellular carcinoma (HCC), with life‐threatening malignant behaviours, often develops
distant metastases and is the fourth most common primary cancer in the world, having taken …