Bone and soft tissue sarcomas account for approximately 15% of pediatric solid malignant
tumors and 1% of adult solid malignant tumors. There are over 50 subtypes of sarcomas …

Neurotrophic factors (NTFs) are involved in the pathophysiology of neurological disorders
such as dementia, stroke and traumatic brain injury (TBI), and constitute molecular targets of …

Cancer is a leading cause of death worldwide and its incidence is unfortunately anticipated
to rise in the next years. On the other hand, vascular endothelial growth factor receptor 2 …

Introduction: Angiogenesis is a vital process for cellular functions in both physiological and
pathophysiological conditions and is one of the hallmarks of cancer progression and …

VEGF plays a crucial role in cancer development, angiogenesis and progression, principally
liver and breast cancer. It is vital to uncover novel chemical candidates of VEGFR inhibitors …

Purpose: This open-label, single-arm, phase II study evaluated the vascular endothelial
growth factor receptor 2 (VEGFR2) tyrosine kinase inhibitor (TKI) rivoceranib in patients with …

Abstract Background Endothelial cells (ECs) and pericytes (PCs) are crucial components of
the vascular system, with ECs lining the inner layer of blood vessels and PCs surrounding …

The identification of a series of attributes or hallmarks that are shared by virtually all cancer
cells constitutes a true milestone in cancer research. The conceptualization of a catalogue of …

Among the factors involved in diabetic retinopathy (DR), nerve growth factor (NGF) and
vascular endothelial growth factor A (VEGFA) have been shown to affect both neuronal …

Brown adipose tissue (BAT) remains active in adults, oxidizing fatty acids or glucose and
releasing energy in the form of heat. Brown adipocytes and enhanced thermogenesis are …