Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse effect of chemotherapy
that is frequently experienced by patients receiving treatment for cancer. CIPN is caused by …

The maintenance of cellular homeostasis involves the participation of multiple organelles.
These organelles are associated in space and time, and either cooperate or antagonize …

Organelles cooperate with each other to control cellular homeostasis and cell functions by
forming close connections through membrane contact sites. Important contacts are present …

Abstract The inositol 1, 4, 5-trisphosphate (IP 3) receptor (IP 3 R) is a Ca 2+-release channel
mainly located in the endoplasmic reticulum (ER). Three IP 3 R isoforms are responsible for …

Calcium signaling in neurons as in other cell types can lead to varied changes in cellular
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …

ABSTRACT Introduction Calpain-1 and calpain-2 are prototypical classical isoforms of the
calpain family of calcium-activated cysteine proteases. Their substrate proteins participate in …

Aim: Colorectal cancer (CRC) is the leading cause of cancer associated death worldwide
and immune checkpoint blockade therapy only benefit a small set of CRC patients. Tumor …

Degeneration of dopaminergic neurons in the substantia nigra causes the motor symptoms
of Parkinson's disease. The mechanisms underlying this age-dependent and region …

Parkinson's disease (PD) is characterized by a progressive deterioration of motor and
cognitive functions. Although death of dopamine neurons is the hallmark pathology of PD …

Chemotherapy‐induced peripheral neuropathy (CIPN) is a common dose‐limiting toxicity
that affects 30%–40% of patients undergoing cancer treatment. Although multiple …