Current ART, determinants for virologic failure and implications for HIV drug resistance: an umbrella review
Objective The purpose of this study is to investigate the incidence of determinants for
virologic failure and to identify predisposing factors to enhance treatment efficacy. Tackling …
virologic failure and to identify predisposing factors to enhance treatment efficacy. Tackling …
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir
D Jochmans, C Liu, K Donckers, A Stoycheva… - MBio, 2023 - Am Soc Microbiol
The SARS-CoV-2 main protease (3CLpro) has an indispensable role in the viral life cycle
and is a therapeutic target for the treatment of COVID-19. The potential of 3CLpro-inhibitors …
and is a therapeutic target for the treatment of COVID-19. The potential of 3CLpro-inhibitors …
Epidemiology of HIV drug resistance in low-and middle-income countries and WHO global strategy to monitor its emergence
S Bertagnolio, MR Jordan, A Giron… - Current Opinion in HIV …, 2022 - journals.lww.com
Epidemiology of HIV drug resistance in low- and middle-incom... : Current Opinion in HIV and
AIDS Epidemiology of HIV drug resistance in low- and middle-income countries and WHO …
AIDS Epidemiology of HIV drug resistance in low- and middle-income countries and WHO …
Nirmatrelvir-resistant SARS-CoV-2 is efficiently transmitted in female Syrian hamsters and retains partial susceptibility to treatment
R Abdelnabi, D Jochmans, K Donckers, B Trüeb… - Nature …, 2023 - nature.com
The SARS-CoV-2 main protease (3CLpro) is one of the promising therapeutic targets for the
treatment of COVID-19. Nirmatrelvir is the first 3CLpro inhibitor authorized for treatment of …
treatment of COVID-19. Nirmatrelvir is the first 3CLpro inhibitor authorized for treatment of …
The Effect of treatment-associated mutations on HIV replication and transmission cycles
MM Johnson, CE Jones, DN Clark - Viruses, 2022 - mdpi.com
HIV/AIDS mortality has been decreasing over the last decade. While promising, this
decrease correlated directly with increased use of antiretroviral drugs. As a natural …
decrease correlated directly with increased use of antiretroviral drugs. As a natural …
Single-center experience evaluating and initiating people with HIV on long-acting cabotegravir/rilpivirine
LA Hill, KK Abulhosn, JF Yin, LP Bamford - Aids, 2023 - journals.lww.com
Objective: To describe our experience evaluating and initiating individuals on long-acting
injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) and evaluate factors associated with …
injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) and evaluate factors associated with …
Transmitted drug resistance to antiretroviral drugs in Spain during the period 2019–2021
L Viñuela, A De Salazar, A Fuentes… - Journal of Medical …, 2023 - Wiley Online Library
To evaluate the prevalence of transmitted drug resistance (TDR) to nucleoside and
nonnucleoside reverse transcriptase inhibitors (NRTI, NNRTI), protease inhibitors (PI), and …
nonnucleoside reverse transcriptase inhibitors (NRTI, NNRTI), protease inhibitors (PI), and …
Changes in Primary HIV-1 Drug Resistance Due to War Migration from Eastern Europe
In recent years, especially as a result of war in Ukraine, enormous movements of migration
to Poland from eastern European countries have been reported, including people living with …
to Poland from eastern European countries have been reported, including people living with …
HIV-1 subtype diversity and factors affecting drug resistance among patients with virologic failure in antiretroviral therapy in Hainan province, China, 2014–2020
YU De E, YJ Xu, LI Mu, Y Yuan, HY Liang… - Biomedical and …, 2023 - Elsevier
Objective This study aimed to determine the HIV-1 subtype distribution and HIV drug
resistance (HIVDR) in patients with ART failure from 2014 to 2020 in Hainan, China …
resistance (HIVDR) in patients with ART failure from 2014 to 2020 in Hainan, China …
HIV-1 transmitted drug resistance in newly diagnosed individuals in Italy over the period 2015–21
Background Transmitted drug resistance (TDR) is still a critical aspect for the management
of individuals living with HIV-1. Thus, its evaluation is crucial to optimize HIV care. Methods …
of individuals living with HIV-1. Thus, its evaluation is crucial to optimize HIV care. Methods …