For more than a century, transplantation of tissues and organs from animals into man,
xenotransplantation, has been viewed as a potential way to treat disease. Ironically, interest …

Cell fusion occurs in development and in physiology and rarely in those settings is it
associated with malignancy. However, deliberate fusion of cells and possibly untoward …

The initiation and progression of cancers reflect the underlying process of somatic evolution,
in which the diversification of heritable phenotypes provides a substrate for natural selection …

Background While the morbidity and mortality from cancer are largely attributable to its
metastatic dissemination, the integral features of the cascade are not well understood. The …

Here we describe isolation and characterization of macrophage-tumor cell fusions (MTFs)
from the blood of pancreatic ductal adenocarcinoma (PDAC) patients. The MTFs were …

A distinctive feature of the SARS-CoV-2 spike protein is its ability to efficiently fuse cells, thus
producing syncytia found in COVID-19 patients. This commentary proposes how this ability …

Oncogenesis is considered to result from chromosomal instability, in addition to oncogene
and tumor-suppressor alterations. Intermediate to aneuploidy and chromosomal instability …

Cell fusion in tumor progression mostly refers to the merging of a cancer cell with a cell that
has migration and immune escape capabilities such as macrophages. Here we show that …

Cell–cell fusion is a physiological process that is hijacked during oncogenesis and promotes
tumour evolution. The main known impact of cell fusion is to promote the formation of …

Whole-genome duplication (WGD) doubles the DNA content in the nucleus and leads to
polyploidy. In whole-organism polyploids, WGD has been implicated in adaptability and the …