Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis

X Li, S Wei, S Niu, X Ma, H Li, M Jing, Y Zhao - Computers in biology and …, 2022 - Elsevier
Abstract Background Huanglian Jiedu Decoction (HLJDD) is a classical herbal formula with
potential efficacy in the treatment of sepsis. However, the main components and potential …

Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations

M Parotto, M Gyöngyösi, K Howe, SN Myatra… - The Lancet …, 2023 - thelancet.com
Individuals with SARS-CoV-2 infection can develop symptoms that persist well beyond the
acute phase of COVID-19 or emerge after the acute phase, lasting for weeks or months after …

Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis

AJ Kwok, A Allcock, RC Ferreira, E Cano-Gamez… - Nature …, 2023 - nature.com
Sepsis arises from diverse and incompletely understood dysregulated host response
processes following infection that leads to life-threatening organ dysfunction. Here we …

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

[HTML][HTML] miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung …

K Shen, X Wang, Y Wang, Y Jia, Y Zhang, K Wang… - Redox biology, 2023 - Elsevier
Background Sepsis is a fatal disease with a high rate of morbidity and mortality, during
which acute lung injury is the earliest and most serious complication. Injury of pulmonary …

The pathophysiology of sepsis and precision-medicine-based immunotherapy

EJ Giamarellos-Bourboulis, AC Aschenbrenner… - Nature …, 2024 - nature.com
Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections

J Schlechte, AZ Zucoloto, I Yu, CJ Doig, MJ Dunbar… - Nature Medicine, 2023 - nature.com
Critically ill patients in intensive care units experience profound alterations of their gut
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections …

Balance cell apoptosis and pyroptosis of caspase-3-activating chemotherapy for better antitumor therapy

L Li, S Wang, W Zhou - Cancers, 2022 - mdpi.com
Simple Summary Chemotherapy has been widely used in clinic to treat various types of
tumors, although severe side effects have been the most critical limitation of this treatment …

A multifunctional nanoparticle mitigating cytokine storm by scavenging multiple inflammatory mediators of sepsis

Z Li, Y Feng, S Zhang, T Li, H Li, D Wang, K Hao… - ACS …, 2023 - ACS Publications
Sepsis is a disease caused by infection, which is characterized by a dysregulated immune
response in the host and affects more than 30 million people worldwide each year …

Epigenetic mechanisms of immune remodeling in sepsis: targeting histone modification

D Wu, Y Shi, H Zhang, C Miao - Cell death & disease, 2023 - nature.com
Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated
immune responses and multiple organ dysfunction. The imbalance between …