Oxidative stress and NRF2/KEAP1/ARE pathway in diabetic kidney disease (DKD): new perspectives

DM Tanase, EM Gosav, MI Anton, M Floria… - Biomolecules, 2022 - mdpi.com
Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …

Endothelial cells as tools to model tissue microenvironment in hypoxia-dependent pathologies

A Majewska, K Wilkus, K Brodaczewska… - International Journal of …, 2021 - mdpi.com
Endothelial cells (ECs) lining the blood vessels are important players in many biological
phenomena but are crucial in hypoxia-dependent diseases where their deregulation …

Protective effects of grape seed proanthocyanidins on the kidneys of diabetic rats through the Nrf2 signalling pathway

Y Ding, H Li, Y Li, D Liu, L Zhang… - Evidence‐based …, 2020 - Wiley Online Library
Background. Diabetic nephropathy (DN) is the most common cause of end‐stage renal
failure. Grape seed proanthocyanidin extract (GSPE) is a powerful antioxidant that is …

Grape seed proanthocyanidins exert a neuroprotective effect by regulating microglial M1/M2 polarisation in rats with spinal cord injury

W Liu, Z Ma, J Kang, A Lin, Z Wang… - Mediators of …, 2022 - Wiley Online Library
Spinal cord injury (SCI) is a highly disabling disorder for which few effective treatments are
available. Grape seed proanthocyanidins (GSPs) are polyphenolic compounds with various …

Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway

X He, X Guo, Z Ma, Y Li, J Kang, G Zhang, Y Gao… - Neuroscience …, 2021 - Elsevier
Grape seed proanthocyanidins (GSP) are natural flavonoids with strong antioxidant and anti-
apoptotic effects. Oxidative stress and neuronal apoptosis are major contributors to spinal …

葡萄籽提取物营养成分组成及其生物学功能研究进展.

周向辉 - Food & Machinery, 2023 - search.ebscohost.com
葡萄籽提取物由于具有较强的抗氧化活性, 通常被用作一种营养保健品或膳食补充剂,
可用于预防炎症, 肿瘤, 动脉粥样硬化等代谢疾病. 文章综述了葡萄籽提取物中的营养成分组成和 …

Solid lipid nanoparticles administering antioxidant grape seed-derived polyphenol compounds: A potential application in aquaculture

A Trapani, MÁ Esteban, F Curci, DE Manno, A Serra… - Molecules, 2022 - mdpi.com
The supply of nutrients, such as antioxidant agents, to fish cells still represents a challenge
in aquaculture. In this context, we investigated solid lipid nanoparticles (SLN) composed of a …

Role of Flavonoids in Modulation of Mitochondria Dynamics during Oxidative Stress

S Kumar, V Chhabra, S Shenoy… - Mini Reviews in …, 2024 - ingentaconnect.com
Background: Flavonoids are a widespread category of naturally occurring polyphenols
distinguished by the flavan nucleus in plant-based foods and beverages, known for their …

Pitaya (Hylocereus lemairei) extracts avoid mitochondrial dysfunction and NF-kβ/NLRP-3-mediated inflammation in endothelial cells under high glucose and are in …

KZ Lodi, C Cassini, FJ Scariot, S Echeverrigaray… - PharmaNutrition, 2023 - Elsevier
Background Pitaya has gained popularity as a dietary alternative for diabetics. However, the
precise molecular basis and biochemical effects are not well understood. This study aimed …

Dual effect of the herbal matcha green tea (Camellia sinensis L. kuntze) supplement in EA. hy926 endothelial cells and Artemia salina

TM Silva, DS Fracasso, APV Visentin, C Cassini… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Matcha green tea (Camellia sinensis) based-supplements
have been widely used since they present a greater content of phenolic compounds than …