The third international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation
Despite recent advances, cytomegalovirus (CMV) infections remain one of the most common
complications affecting solid organ transplant recipients, conveying higher risks of …
complications affecting solid organ transplant recipients, conveying higher risks of …
Antiviral drug resistance of human cytomegalovirus
NS Lurain, S Chou - Clinical microbiology reviews, 2010 - Am Soc Microbiol
The study of human cytomegalovirus (HCMV) antiviral drug resistance has enhanced
knowledge of the virological targets and the mechanisms of antiviral activity. The currently …
knowledge of the virological targets and the mechanisms of antiviral activity. The currently …
Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation
Cytomegalovirus (CMV) continues to be one of the most common infections after solid-organ
transplantation, resulting in significant morbidity, graft loss, and adverse outcomes …
transplantation, resulting in significant morbidity, graft loss, and adverse outcomes …
Antiviral drug resistance as an adaptive process
KK Irwin, N Renzette, TF Kowalik, JD Jensen - Virus evolution, 2016 - academic.oup.com
Antiviral drug resistance is a matter of great clinical importance that, historically, has been
investigated mostly from a virological perspective. Although the proximate mechanisms of …
investigated mostly from a virological perspective. Although the proximate mechanisms of …
Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance
S Chou - Antiviral research, 2020 - Elsevier
Cytomegalovirus (CMV) drug resistance mutation maps are updated with recent information
for polymerase inhibitors, the terminase inhibitor letermovir and the UL97 kinase inhibitor …
for polymerase inhibitors, the terminase inhibitor letermovir and the UL97 kinase inhibitor …
Hospitalization and mortality associated with SARS-CoV-2 viral clades in COVID-19
Abstract The COVID-19 epidemic of 2019–20 is due to the novel coronavirus SARS-CoV-2.
Following first case description in December, 2019 this virus has infected over 10 million …
Following first case description in December, 2019 this virus has infected over 10 million …
Antiviral drug resistance in herpesviruses other than cytomegalovirus
The discovery of acyclovir (ACV), a nucleoside analogue, more than 30 years ago,
represents a milestone in the management of HSV and VZV infections. The modest activity …
represents a milestone in the management of HSV and VZV infections. The modest activity …
Bright and early: Inhibiting human cytomegalovirus by targeting major immediate-early gene expression or protein function
CS Adamson, MM Nevels - Viruses, 2020 - mdpi.com
The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes
lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections …
lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections …
Characterization of cytomegalovirus breakthrough events in a phase 2 prophylaxis trial of letermovir (AIC246, MK 8228)
P Lischka, D Michel… - The Journal of infectious …, 2016 - academic.oup.com
Background The efficacy of different letermovir (AIC246, MK8228) doses (60, 120, and 240
mg/day) against human cytomegalovirus (HCMV) was evaluated in a recent phase 2b dose …
mg/day) against human cytomegalovirus (HCMV) was evaluated in a recent phase 2b dose …
Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations …
The molecular mechanisms of herpes simplex virus (HSV) resistance to antiviral drugs
interfering with viral DNA synthesis reported so far rely on the presence of mutations within …
interfering with viral DNA synthesis reported so far rely on the presence of mutations within …