Targeted and untargeted proteomics approaches in biomarker development

CA Sobsey, S Ibrahim, VR Richard, V Gaspar… - …, 2020 - Wiley Online Library
An enormous amount of research effort has been devoted to biomarker discovery and
validation. With the completion of the human genome, proteomics is now playing an …

Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics

M Adamaki, V Zoumpourlis - Pharmacology & therapeutics, 2021 - Elsevier
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and among the
leading causes of cancer-related death worldwide. It is a highly heterogeneous disease …

LSPR chip for parallel, rapid, and sensitive detection of cancer markers in serum

SS Acimovic, MA Ortega, V Sanz, J Berthelot… - Nano …, 2014 - ACS Publications
Label-free biosensing based on metallic nanoparticles supporting localized surface
plasmon resonances (LSPR) has recently received growing interest (Anker, JN, et al. Nat …

[HTML][HTML] Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre …

CA Sánchez, EI Andahur, R Valenzuela, EA Castellón… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The different prostate cancer (PCa) cell populations (bulk and cancer stem cells, CSCs)
release exosomes that contain miRNAs that could modify the local or premetastatic niche …

Oxidative stress in prostate hyperplasia and carcinogenesis

UK Udensi, PB Tchounwou - Journal of Experimental & Clinical Cancer …, 2016 - Springer
Prostatic hyperplasia (PH) is a common urologic disease that affects mostly elderly men. PH
can be classified as benign prostatic hyperplasia (BPH), or prostate cancer (PCa) based on …

Prostate cancer biomarkers detection using nanoparticles based electrochemical biosensors

S Singh, AAS Gill, M Nlooto, R Karpoormath - Biosensors and …, 2019 - Elsevier
Prostate cancer (PCa) is the most prevalent cancer with a high mortality rate. The early and
accurate detection of PCa can significantly reduce mortality and saves lives. Hence, the …

Merging new-age biomarkers and nanodiagnostics for precision prostate cancer management

KM Koo, PN Mainwaring, SA Tomlins… - Nature Reviews Urology, 2019 - nature.com
The accurate identification and stratified treatment of clinically significant early-stage
prostate cancer have been ongoing concerns since the outcomes of large international …

Label-free impedimetric aptasensor with antifouling surface chemistry: A prostate specific antigen case study

P Jolly, N Formisano, J Tkáč, P Kasák, CG Frost… - Sensors and Actuators B …, 2015 - Elsevier
We here report the development of an aptamer based biosensor for the investigation of
prostate specific antigen (PSA), a biomarker found in blood for prostate cancer (PCa), using …

Significance of the TMPRSS2: ERG gene fusion in prostate cancer

Z Wang, Y Wang, J Zhang, Q Hu… - Molecular …, 2017 - spandidos-publications.com
The transmembrane protease serine 2: v‑ets erythroblastosis virus E26 oncogene homolog
(TMPRSS2: ERG) gene fusion is common in prostate cancer, while its functional role is not …

Nanomaterial-based biosensors for detection of prostate specific antigen

D Damborska, T Bertok, E Dosekova, A Holazova… - Microchimica acta, 2017 - Springer
Screening serum for the presence of prostate specific antigen (PSA) belongs to the most
common approach for the detection of prostate cancer. This review (with 156 refs.) …