Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

Curcumin, a component of a spice native to India, was first isolated in 1815 by Vogel and
Pelletier from the rhizomes of Curcuma longa (turmeric) and, subsequently, the chemical …

Background Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that
stimulates erythropoiesis and regulates iron metabolism. Additional data are needed …

Circulating tumor cells (CTCs) are shed from solid cancers in the form of single or clustered
cells, and the latter display an extraordinary ability to initiate metastasis. Yet, the biological …

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …

Insufficient vessel growth associated with ischemia remains an unresolved issue in vascular
medicine. Mesenchymal stem cells (MSCs) have been shown to promote angiogenesis via a …

AMP-activated protein kinase (AMPK) is known as a pivotal cellular energy sensor,
mediating the adaptation to low energy levels by deactivating anabolic processes and …

Cancer is a disease at the cellular level involving heritable disorders in cellular control
mechanism. Cancer cells also need to adapt their metabolism to survive and multiply under …

Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory
diseases. Concentrated efforts in this area of research are leading to the discovery of a …

Mesenchymal stromal cell (MSC) metabolism plays a crucial role in the microenvironment in
both normal physiology and disease. While MSCs predominantly utilize glycolysis in their …